sentences:  Originally regarded as a rare pathological curiosity, it is now an important focus of research into tumour formation and suppression.The history of TSC research is commonly divided into four periods.In the late 19th century, notable physicians working in European teaching hospitals first described the cortical and dermatological manifestations; these early researchers have been awarded with eponyms such as "Bourneville's disease" and "Pringle's adenoma sebaceum".