sentences:  siRNAs, such as LY2181308, bound to the respective mRNA results in disruption of translation of that particular gene and thus the absence of that protein in the cell.Thus, the use of siRNAs has great potential to be a human therapeutic, as it can target and silence the expression of potentially any protein you want.A problem arises when siRNA expression in a cell cannot be controlled, allowing its constitutive expression to cause toxic side-effects.