sentences:  Flutamide-treated survivin mutant-transduced cells were shown to significantly increase apoptosis by double that of flutamide treatment alone.On the other end, overexpression of the wild-type survivin was found to significantly reduce the apoptosis levels from flutamide treatment compared to flutamide treatment alone.Therefore, these results support the hypothesis that survivin plays a role in the anti-apoptotic nature of the LNCaP cancer cell line and that inhibiting survivin in prostate cancer cells appears to enhance the therapeutic effect of flutamide.