sentences:  By a general hypothesis on peptideric G protein-coupled receptors binding site, Takeda discovered a series of N-benzylcarboxyamides in 1995.One of those compounds, TAK-637 (figure 6), underwent phase II clinical trials for urinary incontinence, depression and irritable bowel syndrome, but the development was discontinued.There are still other compounds that have been researched in the past and even reached clinical trials, and research continues despite the lack of success in clinical trials.