sentences:  Batch adsorption, e.g.onto ion exchange media, is only useful when dealing with smaller samples of plasma, typically 200 mL or less.Batch adsorption recovers the product in a larger volume of elution buffer than does column chromatography or frontal chromatography, and the resulting more dilute product requires concentration, typically on a membrane system, which can lead to loss of product by irreversible adsorption to the membrane.