sentences:  In a traditional "Crithidia fasciculata" kDNA network, initiation of replication is promoted by the unlinking of kDNA minicircles via topoisomerase II.The free minicircles are released into a region between the kinetoplast and the mitochondrial membrane called the kinetoflagellar zone (KFZ).After replication the minicircles migrate by unknown mechanisms to the antipodal protein complexes that contain several replication proteins including an endonuclease, helicase, DNA polymerase, DNA primase, and DNA ligase, which initiate repair of remaining discontinuities in the newly replicated minicircles.