sentences:  Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells.Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone (i.e.a substance that induces activity in the hypophysis) but also functions as a neurotransmitter and neuromodulator.