sentences:  PGE2 was the first immunomodulator to be derived from macrophages and described.PGE2 functions in amplifiying peripheral blood lymphocyte IL-10 transcription and protein production; as well as in deactivating macrophages and T-cells.PGE2 is an immunomodulatory eicosanoid derived from the cell membrane component, arachidonic acid, and is processed in the arachidonic acid cascade