sentences:  Under normal glycemic conditions, only a small fraction of glucose is metabolized through the polyol pathway, as the majority is phosphorylated by hexokinase, and the resulting product, glucose-6-phosphate, is utilized as a substrate for glycolysis or pentose phosphate metabolism.However, in response to the chronic hyperglycemia found in diabetics, glucose flux through the polyol pathway is significantly increased.Up to 33% of total glucose utilization in some tissues can be through the polyol pathway.