sentences:  Specifically, the larger the isoform, the more apo(a) precursor protein accumulates intracellularly in the endoplasmic reticulum.Lp(a) is not fully synthesised until the precursor protein is released from the cell, so the slower rate of production for the larger isoforms limits the plasma concentration.Lp(a) concentrations can vary by more than one thousand between individuals, from <0.2 to >200 mg/dL.