sentences:  If the -NH2 group of anthranoyllycoctonine is removed, giving the compound [[lycoctonine-18-O-benzoate]], the affinity for α7 receptors, as well as for α4β2 receptors is reduced by about a factor of 10 in comparison to MLA.When compared with MLA in the rat phrenic nerve-diaphragm assay, lycoctonine-18-O-benzoate was also about 10x less potent, and a similar reduction in potency was observed in an electrophysiological study involving frog extensor muscle.Even the absence of the methyl group from the methylsuccinimido- ring, as in the alkaloid [[lycaconitine]], reduces the affinity for α7 receptors by a factor of about 20, although there are no references to such use in the last few decades.