sentences:  However, this suggestion was apparently based only on work by Solinas et al.who showed that doses of 0.3-5.6 mg/kg, i.p., in rats, dose-dependently antagonized the [[discriminative-stimulus]] effects of 3 mg/kg [[THC]].Given that the early Soviet work with "mellictine" indicated that as little as ~0.2-0.3 mg/kg, orally, in man (assuming a weight of 60–70 kg, for the sake of making the dose conversion) could produce symptoms of toxicity, and that oral administration of most drugs typically requires more drug than parenteral administration, it is uncertain if MLA will prove to be a practical treatment for either nicotine or cannabis addiction, based on the effective doses required in the rat experiments.