sentences:  These armadas undertook the "Carreira da Índia" ("India Run"), following the sea route around the Cape of Good Hope first opened up by Vasco da Gama in 1497–1499.For about thirty years, from 1503 to 1535, the Portuguese cut into the Venetian spice trade in the Mediterranean.By 1510, the Portuguese throne was pocketing a million cruzados yearly from the spice trade alone, and it was this which led Francis I of France to dub King Manuel I of Portugal "le roi épicier", that is, "the grocer king."