sentences:  However, some subjects could only tolerate single doses of 0.02 g per day without experiencing side-effects.The earliest observation on a relationship between the molecular structure of MLA and a biological activity concerned the effect of the C-18 ester group on acute toxicity.When this group was [[hydrolyzed]], the resulting amino-alcohol (named [[lycoctonine]] as a consequence of its natural occurrence) was found to be much less poisonous to animals than was MLA.