sentences:  During its history, the LRI saw four of its researchers receive the Nobel Prize.The laboratories are associated with a number of major scientific discoveries, including the discovery of the p53 gene, the link between growth factors and oncogenes; the identification of mammalian homologues of the cell cycle regulator cdc2; and the identification of the sex-determining gene SRY.In 1975 Dr Renato Dulbecco, then Deputy Research Director of the Laboratories shared the Nobel Prize for Physiology or Medicine for his work on the interactions between DNA tumour viruses and cells.