sentences:  Acetaldehyde is an intermediate metabolite of ethanol and is responsible for most symptoms of a hangover; its effect on autonomic β receptors is responsible for the vasomotor symptoms.Treatment involves reassuring the patient that the often frightening symptoms will pass, rehydration (fluid replacement) for fluid loss from vomiting, and monitoring for cardiac arrhythmias.Large and prolonged doses of coprine were found to have gonadotoxic effects on rats and dogs in testing.