sentences:  High altitudes also pose serious physiological challenges on the body.Some of these effects are reduced arterial formula_1, the rebalancing of the acid-base content in body fluids, increased hemoglobin, increased RBC synthesis, enhanced circulation, and increased levels of the glycolysis byproduct 2,3 diphosphoglycerate, which promotes off-loading of O2 by hemoglobin in the hypoxic tissues.Environmental factors can play a huge role in the human body's fight for homeostasis.