sentences:  Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure.Recently, Heffernan et al.has developed the most accurate predictor for both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning.