sentences:  However, high doses of deguelin are suspected of having negative effects on the heart, lungs and nerves.The molecular mechanisms include the induction of apoptosis, mediated through AKT/PKB signaling pathways in malignant and premaligant human bronchial epithelia (HBE) cells, with only minimal effects on normal HBE cells.Deguelin inhibits AKT by both Phosphoinositol-3-phosphate kinase (PI3K)-dependent and PI3K-independent pathways.