sentences:  In the mid-13th century, the emergence of formal medical education in several European universities fueled a demand for comprehensive textbooks.Instructors from the influential Scuola Medica Salernitana popularized the practice of binding other treatises together with their manuscript copies of the Isagoge.These included Hippocrates’ Prognostics as well as his Aphorisms, Theophilus Protospatharius's De Urinis and De Pulsibus and many other classic works.