sentences:  These missions were some of the most populous in South America with 26,362 inhabitants, according to a Jesuit census, and many more in the surrounding areas.In 1754 the Jesuits surrendered control of the missions, but the Guaraní led by Sepé Tiaraju, refused to comply with the order to relocate.Efforts by the Spanish army in 1754 to forcefully remove the Guarani from the missions failed.