sentences:  The garden was established on December 1, 1545, by Cosimo I de' Medici, Grand Duke of Tuscany, and is Europe's third oldest, behind the Orto Botanico di Pisa and the Orto Botanico di Padova.It was first laid out by landscape gardener Niccolò Pericoli to a botanical system and plantings chosen by Luca Ghini, and rose to prominence under Cosimo III, with Pier Antonio Micheli as its director.As was typical of early European botanical gardens, its prime interest was in medicinal plants.