sentences:  Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g.in the insulin-secreting pancreatic beta cells and many other cells.Since CICR is a positive-feedback system, it has been of great interest to elucidate the mechanism(s) responsible for its termination.