sentences:  This is very different from transition state stabilization in water, where the water molecules must pay with "reorganization energy".In order to stabilize ionic and charged states.Thus, the catalysis is associated with the fact that the enzyme polar groups are preorganized 
  
  The magnitude of the electrostatic field exerted by an enzyme's active site has been shown to be highly correlated with the enzyme's catalytic rate enhancement
  
  Binding of substrate usually excludes water from the active site, thereby lowering the local dielectric constant to that of an organic solvent.