sentences:  Another group of mutant glycoside hydrolases termed thioglycoligases can be formed by site-directed mutagenesis of the acid-base residue of a retaining glycoside hydrolase.Thioglycoligases catalyze the condensation of activated glycosides and various thiol containing acceptors.Various glycoside hydrolases have shown efficacy in degrading matrix polysaccharides within the extracellular polymeric substance (EPS) of microbial biofilms.