sentences:  OLIG1 has been shown to be critical in developmental myelination and may also be important in remyelination.OLIG2 and TRF4 have also been shown to be important especially in the Wnt-β-Catenin Pathway, most likely in inhibiting remyelination.NKX2-2 is a gene coding for a protein that may increase the number of OPCs in low amounts, possibly working with OLIG2 in some way to differentiate OPCs to mature oligodendrocytes.