sentences:  Furthermore, CASQ2 modulates the CICR mechanism by lengthening to process to functionally recharge the sarcoplamsic reticulum's calcium ion stores.A lack of or mutation in CSQ2 has been directly associated with catecholaminergic polymorphic ventricular tachycardia (CPVT).A mutation can have a significant effect if it disrupts the linear polymerization ability of CASQ2, which directly accounts for its high-capacity to bind Ca2+.