sentences:  Calsequestrin is also secreted in the gut where it deprives bacteria of calcium ions..
  
  Cardiac calsequestrin (CASQ2) plays an integral role in cardiac regulation.Mutations in the cardiac calsequestrin gene have been associated with cardiac arrhythmia and sudden death.CASQ2 is thought to have a role in regulating cardiac excitation-contraction coupling and calcium-induced calcium release (CICR) in the heart, as overexpression of CASQ2 has been shown to substantially raise the magnitude of cell-averaged ICA-induced calcium transients and spontaneous calcium sparks in isolated heart cells.