Alright, let's work through 4521 times 4978 step by step
4521 × 4978 = 4978 × (4521)
+ 4978 × 1 giving us 4978
+ 4978 × 20 what gives us 99560
+ 4978 × 500 giving us 2489000
+ 4978 × 4000 that equals 19912000

= 22505538
