Alright, let's work through 4522 times 6453 step by step
4522 × 6453 = 6453 × (4522)
+ 6453 × 2 producing 12906
+ 6453 × 20 resulting in 129060
+ 6453 × 500 giving us 3226500
+ 6453 × 4000 that equals 25812000

= 29180466
