Alright, let's solve this problem step by step. We have 74001 and 19949, and we're subtracting the second number from the first.

Step 1: We'll start by subtracting the digit 9 and the borrow 0 from 1 in column 1 and get -8.
We add -8 to 10 and get 2 as the first digit of the result.

Step 2: We'll start by subtracting the digit 4 and the borrow 1 from 0 in column 2 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 3: We'll start by subtracting the digit 9 and the borrow 1 from 0 in column 3 and get -10.
We add -10 to 10 and get 0 as the next digit of the result.

Step 4: We'll start by subtracting the digit 9 and the borrow 1 from 4 in column 4 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 5: We'll start by subtracting the digit 1 and the borrow 1 from 7 in column 5 and get 5.
5 is the next digit of our result.

So, 74001 - 19949 = 54052.