We can solve this together! We're beginning with 5821 and removing 5253 from it.

Step 1: We'll start by subtracting the digit 3 and the borrow 0 from 1 in column 1 and get -2.
We add -2 to 10 and get 8 as the first digit of the result.

Step 2: We'll start by subtracting the digit 5 and the borrow 1 from 2 in column 2 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 3: We'll start by subtracting the digit 2 and the borrow 1 from 8 in column 3 and get 5.
5 is the next digit of our result.

Step 4: We'll start by subtracting the digit 5 and the borrow 0 from 5 in column 4 and get 0.
0 is the next digit of our result.

So, 5821 - 5253 = 568.