Sure thing! We've got 750849 and 77380, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 9 in column 1 and get 9.
9 is the first digit of our result.

Step 2: We'll start by subtracting the digit 8 and the borrow 0 from 4 in column 2 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 3: We'll start by subtracting the digit 3 and the borrow 1 from 8 in column 3 and get 4.
4 is the next digit of our result.

Step 4: We'll start by subtracting the digit 7 and the borrow 0 from 0 in column 4 and get -7.
We add -7 to 10 and get 3 as the next digit of the result.

Step 5: We'll start by subtracting the digit 7 and the borrow 1 from 5 in column 5 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 6: We'll start by subtracting the digit 0 and the borrow 1 from 7 in column 6 and get 6.
6 is the next digit of our result.

So, 750849 - 77380 = 673469.