Alright, let's work through 5281 times 8216 step by step
5281 × 8216 = 8216 × (5281)
+ 8216 × 1 giving us 8216
+ 8216 × 80 that equals 657280
+ 8216 × 200 that equals 1643200
+ 8216 × 5000 giving us 41080000

= 43388696
