No problem, let's work through this together. We're starting with 80875 and are subtracting 59121 from it.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 5 in column 1 and get 4.
4 is the first digit of our result.

Step 2: We'll start by subtracting the digit 2 and the borrow 0 from 7 in column 2 and get 5.
5 is the next digit of our result.

Step 3: We'll start by subtracting the digit 1 and the borrow 0 from 8 in column 3 and get 7.
7 is the next digit of our result.

Step 4: We'll start by subtracting the digit 9 and the borrow 0 from 0 in column 4 and get -9.
We add -9 to 10 and get 1 as the next digit of the result.

Step 5: We'll start by subtracting the digit 5 and the borrow 1 from 8 in column 5 and get 2.
2 is the next digit of our result.

So, 80875 - 59121 = 21754.