Okay, let's tackle this math problem. We're starting with 64520 and subtracting 23338.

Step 1: We'll start by subtracting the digit 8 and the borrow 0 from 0 in column 1 and get -8.
We add -8 to 10 and get 2 as the first digit of the result.

Step 2: We'll start by subtracting the digit 3 and the borrow 1 from 2 in column 2 and get -2.
We add -2 to 10 and get 8 as the next digit of the result.

Step 3: We'll start by subtracting the digit 3 and the borrow 1 from 5 in column 3 and get 1.
1 is the next digit of our result.

Step 4: We'll start by subtracting the digit 3 and the borrow 0 from 4 in column 4 and get 1.
1 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 6 in column 5 and get 4.
4 is the next digit of our result.

So, 64520 - 23338 = 41182.