Alright, let's solve this problem step by step. We have 457650 and 22876, and we're subtracting the second number from the first.

Step 1: We'll start by subtracting the digit 6 and the borrow 0 from 0 in column 1 and get -6.
We add -6 to 10 and get 4 as the first digit of the result.

Step 2: We'll start by subtracting the digit 7 and the borrow 1 from 5 in column 2 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 3: We'll start by subtracting the digit 8 and the borrow 1 from 6 in column 3 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 4: We'll start by subtracting the digit 2 and the borrow 1 from 7 in column 4 and get 4.
4 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 5 in column 5 and get 3.
3 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 4 in column 6 and get 4.
4 is the next digit of our result.

So, 457650 - 22876 = 434774.