Okay, let's tackle this math problem. We're starting with 250881 and subtracting 15044.

Step 1: We'll start by subtracting the digit 4 and the borrow 0 from 1 in column 1 and get -3.
We add -3 to 10 and get 7 as the first digit of the result.

Step 2: We'll start by subtracting the digit 4 and the borrow 1 from 8 in column 2 and get 3.
3 is the next digit of our result.

Step 3: We'll start by subtracting the digit 0 and the borrow 0 from 8 in column 3 and get 8.
8 is the next digit of our result.

Step 4: We'll start by subtracting the digit 5 and the borrow 0 from 0 in column 4 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 5: We'll start by subtracting the digit 1 and the borrow 1 from 5 in column 5 and get 3.
3 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 6 and get 2.
2 is the next digit of our result.

So, 250881 - 15044 = 235837.