Alright, ready to do some subtraction? We're taking 27372 and subtracting 11221 from it.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 2 in column 1 and get 1.
1 is the first digit of our result.

Step 2: We'll start by subtracting the digit 2 and the borrow 0 from 7 in column 2 and get 5.
5 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 3 in column 3 and get 1.
1 is the next digit of our result.

Step 4: We'll start by subtracting the digit 1 and the borrow 0 from 7 in column 4 and get 6.
6 is the next digit of our result.

Step 5: We'll start by subtracting the digit 1 and the borrow 0 from 2 in column 5 and get 1.
1 is the next digit of our result.

So, 27372 - 11221 = 16151.