No problem, we've got 2281 and 4621 to multiply
2281 × 4621 = 4621 × (2281)
+ 4621 × 1 giving us 4621
+ 4621 × 80 resulting in 369680
+ 4621 × 200 resulting in 924200
+ 4621 × 2000 that results in 9242000

= 10540501
