No problem, let's work through this together. We're starting with 98780 and are subtracting 52366 from it.

Step 1: We'll start by subtracting the digit 6 and the borrow 0 from 0 in column 1 and get -6.
We add -6 to 10 and get 4 as the first digit of the result.

Step 2: We'll start by subtracting the digit 6 and the borrow 1 from 8 in column 2 and get 1.
1 is the next digit of our result.

Step 3: We'll start by subtracting the digit 3 and the borrow 0 from 7 in column 3 and get 4.
4 is the next digit of our result.

Step 4: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 4 and get 6.
6 is the next digit of our result.

Step 5: We'll start by subtracting the digit 5 and the borrow 0 from 9 in column 5 and get 4.
4 is the next digit of our result.

So, 98780 - 52366 = 46414.