Alright, ready to do some subtraction? We're taking 53389 and subtracting 19220 from it.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 9 in column 1 and get 9.
9 is the first digit of our result.

Step 2: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 2 and get 6.
6 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 3 in column 3 and get 1.
1 is the next digit of our result.

Step 4: We'll start by subtracting the digit 9 and the borrow 0 from 3 in column 4 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 5: We'll start by subtracting the digit 1 and the borrow 1 from 5 in column 5 and get 3.
3 is the next digit of our result.

So, 53389 - 19220 = 34169.