Sure thing! We've got 4466 and 641, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 6 in column 1 and get 5.
5 is the first digit of our result.

Step 2: We'll start by subtracting the digit 4 and the borrow 0 from 6 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 6 and the borrow 0 from 4 in column 3 and get -2.
We add -2 to 10 and get 8 as the next digit of the result.

Step 4: We'll start by subtracting the digit 0 and the borrow 1 from 4 in column 4 and get 3.
3 is the next digit of our result.

So, 4466 - 641 = 3825.