Alright, let's solve this problem step by step. We have 95293 and 51051, and we're subtracting the second number from the first.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 3 in column 1 and get 2.
2 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 9 in column 2 and get 4.
4 is the next digit of our result.

Step 3: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 3 and get 2.
2 is the next digit of our result.

Step 4: We'll start by subtracting the digit 1 and the borrow 0 from 5 in column 4 and get 4.
4 is the next digit of our result.

Step 5: We'll start by subtracting the digit 5 and the borrow 0 from 9 in column 5 and get 4.
4 is the next digit of our result.

So, 95293 - 51051 = 44242.