Let's dive into this subtraction. We'll start with 49880 and subtract 25157 from it.

Step 1: We'll start by subtracting the digit 7 and the borrow 0 from 0 in column 1 and get -7.
We add -7 to 10 and get 3 as the first digit of the result.

Step 2: We'll start by subtracting the digit 5 and the borrow 1 from 8 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 1 and the borrow 0 from 8 in column 3 and get 7.
7 is the next digit of our result.

Step 4: We'll start by subtracting the digit 5 and the borrow 0 from 9 in column 4 and get 4.
4 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 4 in column 5 and get 2.
2 is the next digit of our result.

So, 49880 - 25157 = 24723.