Okay, let's tackle this math problem. We're starting with 375529 and subtracting 22206.

Step 1: We'll start by subtracting the digit 6 and the borrow 0 from 9 in column 1 and get 3.
3 is the first digit of our result.

Step 2: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 5 in column 3 and get 3.
3 is the next digit of our result.

Step 4: We'll start by subtracting the digit 2 and the borrow 0 from 5 in column 4 and get 3.
3 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 7 in column 5 and get 5.
5 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 6 and get 3.
3 is the next digit of our result.

So, 375529 - 22206 = 353323.