Let's get this math done. We have 366003 and 4850, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 1 and get 3.
3 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 0 in column 2 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 3: We'll start by subtracting the digit 8 and the borrow 1 from 0 in column 3 and get -9.
We add -9 to 10 and get 1 as the next digit of the result.

Step 4: We'll start by subtracting the digit 4 and the borrow 1 from 6 in column 4 and get 1.
1 is the next digit of our result.

Step 5: We'll start by subtracting the digit 0 and the borrow 0 from 6 in column 5 and get 6.
6 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 6 and get 3.
3 is the next digit of our result.

So, 366003 - 4850 = 361153.