Alright, let's work through 4442 times 4543 step by step
4442 × 4543 = 4543 × (4442)
+ 4543 × 2 resulting in 9086
+ 4543 × 40 what gives us 181720
+ 4543 × 400 which equals 1817200
+ 4543 × 4000 producing 18172000

= 20180006
