OK, let's do this. We've got 88860 and 22245, and we're subtracting the second number from the first.

Step 1: We'll start by subtracting the digit 5 and the borrow 0 from 0 in column 1 and get -5.
We add -5 to 10 and get 5 as the first digit of the result.

Step 2: We'll start by subtracting the digit 4 and the borrow 1 from 6 in column 2 and get 1.
1 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 3 and get 6.
6 is the next digit of our result.

Step 4: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 4 and get 6.
6 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 5 and get 6.
6 is the next digit of our result.

So, 88860 - 22245 = 66615.