Alright, ready to do some subtraction? We're taking 780729 and subtracting 53051 from it.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 9 in column 1 and get 8.
8 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 2 in column 2 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 3: We'll start by subtracting the digit 0 and the borrow 1 from 7 in column 3 and get 6.
6 is the next digit of our result.

Step 4: We'll start by subtracting the digit 3 and the borrow 0 from 0 in column 4 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 5: We'll start by subtracting the digit 5 and the borrow 1 from 8 in column 5 and get 2.
2 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 7 in column 6 and get 7.
7 is the next digit of our result.

So, 780729 - 53051 = 727678.