Alright, let's solve this problem step by step. We have 590680 and 44537, and we're subtracting the second number from the first.

Step 1: We'll start by subtracting the digit 7 and the borrow 0 from 0 in column 1 and get -7.
We add -7 to 10 and get 3 as the first digit of the result.

Step 2: We'll start by subtracting the digit 3 and the borrow 1 from 8 in column 2 and get 4.
4 is the next digit of our result.

Step 3: We'll start by subtracting the digit 5 and the borrow 0 from 6 in column 3 and get 1.
1 is the next digit of our result.

Step 4: We'll start by subtracting the digit 4 and the borrow 0 from 0 in column 4 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 5: We'll start by subtracting the digit 4 and the borrow 1 from 9 in column 5 and get 4.
4 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 5 in column 6 and get 5.
5 is the next digit of our result.

So, 590680 - 44537 = 546143.