Alright, ready to do some subtraction? We're taking 78378 and subtracting 4448 from it.

Step 1: We'll start by subtracting the digit 8 and the borrow 0 from 8 in column 1 and get 0.
0 is the first digit of our result.

Step 2: We'll start by subtracting the digit 4 and the borrow 0 from 7 in column 2 and get 3.
3 is the next digit of our result.

Step 3: We'll start by subtracting the digit 4 and the borrow 0 from 3 in column 3 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 4: We'll start by subtracting the digit 4 and the borrow 1 from 8 in column 4 and get 3.
3 is the next digit of our result.

Step 5: We'll start by subtracting the digit 0 and the borrow 0 from 7 in column 5 and get 7.
7 is the next digit of our result.

So, 78378 - 4448 = 73930.