Okay, let's tackle this math problem. We're starting with 359379973 and subtracting 245121450.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 1 and get 3.
3 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 7 in column 2 and get 2.
2 is the next digit of our result.

Step 3: We'll start by subtracting the digit 4 and the borrow 0 from 9 in column 3 and get 5.
5 is the next digit of our result.

Step 4: We'll start by subtracting the digit 1 and the borrow 0 from 9 in column 4 and get 8.
8 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 7 in column 5 and get 5.
5 is the next digit of our result.

Step 6: We'll start by subtracting the digit 1 and the borrow 0 from 3 in column 6 and get 2.
2 is the next digit of our result.

Step 7: We'll start by subtracting the digit 5 and the borrow 0 from 9 in column 7 and get 4.
4 is the next digit of our result.

Step 8: We'll start by subtracting the digit 4 and the borrow 0 from 5 in column 8 and get 1.
1 is the next digit of our result.

Step 9: We'll start by subtracting the digit 2 and the borrow 0 from 3 in column 9 and get 1.
1 is the next digit of our result.

So, 359379973 - 245121450 = 114258523.