Alright, let's work through 45221057 times 53621641 step by step
45221057 × 53621641 = 53621641 × (45221057)
+ 53621641 × 7 producing 375351487
+ 53621641 × 50 that results in 2681082050
+ 53621641 × 000 giving us 0
+ 53621641 × 1000 which equals 53621641000
+ 53621641 × 20000 producing 1072432820000
+ 53621641 × 200000 yielding 10724328200000
+ 53621641 × 5000000 producing 268108205000000
+ 53621641 × 40000000 producing 2144865640000000

= 2424827284094537
