We can solve this together! We're beginning with 78410 and removing 42149 from it.

Step 1: We'll start by subtracting the digit 9 and the borrow 0 from 0 in column 1 and get -9.
We add -9 to 10 and get 1 as the first digit of the result.

Step 2: We'll start by subtracting the digit 4 and the borrow 1 from 1 in column 2 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 3: We'll start by subtracting the digit 1 and the borrow 1 from 4 in column 3 and get 2.
2 is the next digit of our result.

Step 4: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 4 and get 6.
6 is the next digit of our result.

Step 5: We'll start by subtracting the digit 4 and the borrow 0 from 7 in column 5 and get 3.
3 is the next digit of our result.

So, 78410 - 42149 = 36261.