Let's get this math done. We have 50543 and 24870, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 1 and get 3.
3 is the first digit of our result.

Step 2: We'll start by subtracting the digit 7 and the borrow 0 from 4 in column 2 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 3: We'll start by subtracting the digit 8 and the borrow 1 from 5 in column 3 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 4: We'll start by subtracting the digit 4 and the borrow 1 from 0 in column 4 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 5: We'll start by subtracting the digit 2 and the borrow 1 from 5 in column 5 and get 2.
2 is the next digit of our result.

So, 50543 - 24870 = 25673.