Alright, ready to do some subtraction? We're taking 577721 and subtracting 48506 from it.

Step 1: We'll start by subtracting the digit 6 and the borrow 0 from 1 in column 1 and get -5.
We add -5 to 10 and get 5 as the first digit of the result.

Step 2: We'll start by subtracting the digit 0 and the borrow 1 from 2 in column 2 and get 1.
1 is the next digit of our result.

Step 3: We'll start by subtracting the digit 5 and the borrow 0 from 7 in column 3 and get 2.
2 is the next digit of our result.

Step 4: We'll start by subtracting the digit 8 and the borrow 0 from 7 in column 4 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 5: We'll start by subtracting the digit 4 and the borrow 1 from 7 in column 5 and get 2.
2 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 5 in column 6 and get 5.
5 is the next digit of our result.

So, 577721 - 48506 = 529215.