Y ffordd orau o reoli rhai o ymyriadau ein Fframwaith (e.e. darparu mynediad at gyllid i fusnesau, sgiliau a chyflogadwyedd ac ati) fydd gwneud hynny ar lefel Cymru gyfan; er enghraifft er mwyn elwa ar arbedion maint, cydlynu a gwneud y gorau o arloesedd ar draws rhwydwaith o bartneriaethau, neu fanteisio ar arbenigedd technegol penodol, na fydd o reidrwydd ar gael ym mhob rhanbarth. Bydd angen i brosiectau cenedlaethol, yn eu hachos busnes ar gyfer cyllid, nodi sut y byddant yn cyflawni i’r graddau mwyaf posibl yn erbyn amcanion strategol ein Fframwaith i gyd-fynd â blaenoriaethau ehangach Llywodraeth Cymru, a amlinellir ar lefel genedlaethol. Bydd angen iddynt ddangos hefyd bod ymgysylltu llawn wedi digwydd â’r rhanbarthau fel bod buddsoddiadau o'r fath yn cael eu cynllunio ar gyfer y bobl a'r lleoedd y bwriedir iddynt eu helpu a’u bod yn canolbwyntio ar y bobl a’r lleoedd hynny.
Some interventions through our Framework (e.g. the provision of access to finance for businesses, skills and employability etc.) will be best prioritised and managed at a Wales-wide level; for example to benefit from economies of scale, to co-ordinate and optimise innovation across a network of partnerships, or to take advantage of specific technical expertise, not necessarily replicated across all regions. National interventions will need to set out how they will maximise delivery against our Framework’s strategic objectives to align with wider Welsh Government priorities set out at the national level. They will also need to demonstrate that full engagement has taken place with the regions so that such investments are designed and focused on the people and places they are intended to help.