Mae'r strategaeth yn argymell defnyddio’r brechlyn Imvanex yn rhan o strategaeth frechu adweithiol i dargedu’r bobl hynny sy’n wynebu risg uwch o ddod i gysylltiad â’r clefyd. Maent wedi argymell rhaglen frechu cyn-gysylltiol ar gyfer y grwpiau canlynol:Dynion hoyw, deurywiol, neu ddynion sy'n cael rhyw gyda dynion sydd â nifer fawr o gysylltiadauRhai gweithwyr gofal iechyd sy’n wynebu risg o ddod i gysylltiad â’r clefyd, gan rhai sy'n gweithio mewn gwasanaethau iechyd rhywiol ac mewn unedau ar gyfer clefydau heintus (HCID) sydd â chanlyniadau pellgyrhaeddol
The strategy recommends the use of the Imvanex vaccine as part of a reactive vaccination strategy targeting a those people who are at an increased risk of exposure. They have recommended a pre-exposure vaccination programme for the following groups:Gay, bisexual or men who have sex with men with a large number of contactsSome healthcare workers at risk of exposure, including some working in sexual health services and high consequence infectious disease (HCID) units.