Mae Frances wedi dal nifer o swyddi yn Adran Iechyd a Gwasanaethau Cymdeithasol Llywodraeth Cymru. Ymunodd ddiwedd 2013 a bu’n gweithio ar newid gwasanaethau’r GIG, noddi Gwasanaeth Gwybodeg GIG Cymru, gan oruchwylio’r gwaith o ddatblygu a chyflawni’r strategaeth ddigidol ar gyfer y system iechyd a gofal yng Nghymru, a hyrwyddo arloesedd yn GIG Cymru.
Frances has held a number of posts within the Health and Social Services Department, Welsh Government, joining in late 2013 and working on NHS service change, sponsorship of the NHS Wales Informatics Service overseeing the development and delivery of the digital strategy for the health and care system in Wales  and promoting innovation within  NHS Wales.