Gosodwyd targed heriol gan y Fframwaith am ostyngiad o 40% yng nghyfanswm y bobl sy'n cael eu lladd neu eu niweidio'n ddifrifol ar ffyrdd Cymru erbyn 2020.  Cafodd dau o grwpiau risg uchel eu nodi, a gosodwyd targedau penodol am ostyngiad o 25% yn nifer y beicwyr modur sy'n cael eu lladd neu eu niweidio'n ddifrifol a gostyngiad o 40% yn nifer y bobl ifanc sy'n cael eu lladd neu eu niweidio'n ddifrifol.  Roedd y tri targed wedi'u gosod yn erbyn gwaelodlin 2004-08.
The Framework set a challenging target for a 40% reduction in the total number of people killed or seriously injured on Welsh roads by 2020.  Two high risk groups were identified and specific targets set for a 25% reduction in the number of motorcyclists killed or seriously injured and a 40% reduction in the number of young people killed or seriously injured.  All three targets were set against a 2004-08 baseline.