Mae Sêr Cymru II am adeiladu ar lwyddiant rhaglen wreiddiol Sêr Cymru a arweiniodd at sefydlu pedair Cadair Prifysgol Sêr Cymru a thri rhwydwaith ymchwil yng Nghymru ym meysydd Gwyddoniaeth, Peirianneg, Mathemateg a Meddygaeth (STEMM).
Sêr Cymru II aims to build on the success of the original Sêr Cymru programme, which supported the establishment of four Sêr Cymru Chairs and three research networks in Wales across STEMM (Science, Technology, Engineering, Maths and Medicine) subject areas.