O dan Siarter Brenhinol 2006 yr Amgueddfa, mae gan Amgueddfa Cymru 16 o Ymddiriedolwyr. Caiff naw, gan gynnwys y Llywydd a'r Is-lywydd, eu penodi gan Weinidogion Cymru, a saith, gan gynnwys y Trysorydd, eu penodi gan yr Amgueddfa ei hun.
Under the Museum’s 2006 Royal Charter, Amgueddfa Cymru has 16 trustees – nine, including the President and Vice President, are appointed by Welsh Ministers and the remainder, including the treasurer, are appointed by the National Museum