Yn ogystal ag angen cymuned fyddai'n fodlon lleoli CGD yng Nghymru, bydd angen cymeradwyaeth i’w achosion diogelwch ar RWM gan y Swyddfa Rheoleiddio Niwclear (ONR) o ran diogelwch a sicrwydd niwclear, a chan Gyfoeth Naturiol Cymru o ran diogelu iechyd pobl a'r amgylchedd. Bydd agen cymeradwyaeth y system gynllunio yng Nghymru ar gyfer unrhyw CGD yng Nghymru.
In addition to needing a willing host community, for a GDF in Wales, RWM will also need to gain approval for safety cases from the Office for Nuclear Regulation (ONR) in respect of nuclear safety and security, and Natural Resources Wales in respect of protection of human health and the environment.  Any GDF in Wales would also need approval through the planning system in Wales.