Mae gan Gymru hanes balch o gefnogi ymchwil ac arloesi blaengar ac mae yn cystadlu’n fyd-eang yn y maes hwn. Mae’r rhai sydd wedi elwa o gefnogaeth Llywodraeth Cymru yn cynnwys AMRC ym Mrychdyn, MSparc ar Ynys Mȏn, canolfan ymchwil milfeddygol Aberystwyth, y Ganolfan Ecsbloetio Ddigidol Genedlaethol yng Nglyn Ebwy a chlwstwr lled-ddargludyddion cyfansawdd De Cymru.
Wales has a proud history of supporting cutting-edge research and innovation and has been a globally-engaged nation in this area. Those to have benefited from Welsh Government support include the AMRC in Broughton, MSparc on Anglesey, the Aberystwyth-based veterinary research hub, the National Digital Exploitation Centre in Ebbw Vale and South Wales' compound semiconductor cluster.