Mae cysylltiadau cryf wedi bodoli rhwng Cymru a Gogledd America ers tro. Mae'r cysylltiadau hynny i'w gweld ym maes busnes, diwylliant, iaith ac addysg. Wrth i'n perthynas â'r Undeb Ewropeaidd symud i gyfnod newydd, mae'n bwysig cynnal cysylltiadau busnes a masnach agos gyda'n marchnadoedd pwysicaf. Yr Unol Daleithiau yw mewnfuddsoddwr mwyaf Cymru, gyda thua 320 o gwmnïau dan berchnogaeth yr UDA wedi'u lleoli yng Nghymru sy’n cyflogi bron i 50,000 o bobl. Mae Cymru hefyd yn gartref i 40 o gwmnïau dan berchnogaeth Canada.
There are strong ties between Wales and North America, spanning business, culture, language and education. As our relationship with the European Union moves to a new phase it is important to maintain close business and trading links with our most important markets.  The United States is Wales’ largest inward investor, with around 320 US-owned companies employing almost 50,000 people in Wales, while Wales is also home to 40 Canadian-owned companies.