Sefydlwyd y Cynllun Cenedlaethol Danfon Presgripsiynau gan Wirfoddolwyr a Gwasanaeth y Post Brenhinol mewn ymateb i COVID-19 er mwyn sicrhau bod meddyginiaethau presgripsiwn yn parhau i fod ar gael i'r rhai sy'n gwarchod eu hunain, a'r rhai sy'n hunanynysu heb unrhyw gefnogaeth arall, yn ystod y cyfyngiadau symud cenedlaethol. Cyflwynwyd y ddau wasanaeth i ychwanegu at gapasiti trefniadau darparu meddyginiaethau sy'n bodoli eisoes gan fferyllfeydd cymunedol a meddygon fferyllol yng Nghymru, yn dilyn galw cynyddol yn sgil camau a gymerwyd i leihau lledaeniad y coronafeirws. Cafodd ei sefydlu o fewn pum wythnos yn unig i pan ofynnwyd i bobl warchod eu hunain i ddechrau yng Nghymru, a chafodd cyfanswm o 7,984 o feddyginiaethau eu darparu mewn dim ond 5 mis.
The National Volunteer Prescription Delivery Scheme and the Royal Mail Service were established in response to COVID-19 to ensure prescription medicines continued to be made available to those shielding, and those self-isolating with no other means of support, during national lockdown.  Both were introduced to supplement the capacity and resilience of pre-existing medicines delivery arrangements operated by community pharmacies and dispensing doctors in Wales, following an increased demand resulting from measures taken to reduce the spread of Coronavirus. Established within just five weeks of shielding being introduced in Wales, a total of 7,984 medicines deliveries were made in just 5 months.