Bydd Sêr Cymru’n rhoi nawdd ar gyfer sefydlu rhwydwaith ymchwil cenedlaethol cydweithredol yn y tri maes Her Fawr a nodir yn Gwyddoniaeth i Gymru: Uwch Beirianneg a Deunyddiau; Gwyddorau Bywyd ac Iechyd; a Carbon Isel, Ynni a'r Amgylchedd.  Mae ganddynt gysylltiad agos â thri o'r sectorau busnes yr wyf wedi dewis canolbwyntio arnynt i roi hwb i economi Cymru.
Sêr Cymru will support the establishment of a collaborative national research network in each of the three Grand Challenge areas identified in Science for Wales: Advanced Engineering and Materials; Life Sciences and Health; and Low Carbon, Energy and Environment. These are closely affiliated to three of the priority business sectors already identified within the Welsh economy.