O ran rheoli rhaglen 2014-2020, bydd Cymru (drwy Swyddfa Cyllid Ewropeaidd Cymru) yn cymryd yr awenau, gan weithio mewn partneriaeth ag Awdurdodau Iwerddon. Bydd yn adeiladu ar yr hyn a gyflawnodd rhaglen 2007-2013 (a reolwyd gan Gynulliad Rhanbarthol De a Dwyrain Iwerddon), a roddodd €49.5 miliwn (tua £41 miliwn) o gymorth ariannol i 41 o brosiectau cydweithredol drwy Gronfa Datblygu Rhanbarthol Ewrop.
Wales (through the Welsh European Funding Office) will lead on the management of the 2014–2020 programme working in close partnership with the Irish Authorities, and will build on  the achievements of the 2007–2013 programme (managed by the Southern and Eastern Regional Assembly), which has supported 41 collaborative projects with €49.5m (around £41m) from the European Regional Development Fund.