Mae Llywodraeth Cymru wedi bod yn gweithio gyda GIG Lloegr ac Adran Iechyd San Steffan, ynghyd â chynrychiolwyr o Fyrddau Iechyd Lleol Cymru, Grwpiau Comisiynu Clinigol yn Lloegr, Pwyllgor Gwasanaethau Iechyd Arbenigol Cymru (WHSSC) a byrddau sy'n cynrychioli cleifion i adnewyddu'r Protocol Trawsffiniol y GIG presennol, a oedd wedi bod ar waith ers 2013.
The Welsh Government has been working with NHS England and the Department of Health, along with representatives from Welsh Local Health Boards, English Clinical Commissioning Groups, the Welsh Health Specialised Services Committee (WHSSC) and patient representative bodies to refresh the existing NHS Cross Border Protocol, which had been in place since 2013.