PSB
PSB may refer to:

Education
 Paris School of Business, a private business school located in Paris
 Penn State Behrend, a commonwealth Pennsylvania State University campus in Erie, PA.
 Public Schools Branch, the English school district of Prince Edward Island, Canada
 Public Schools of Brookline, a school district of Brookline, Massachusetts, United States

Music 
 Pet Shop Boys, an English musical duo
 Plus-Tech Squeeze Box, a Japanese Shibuya-kei band
 PSB Speakers, a Canadian loudspeaker company
 Public Service Broadcasting (band), a British electronic trio

Organisations 
 Brunei History Centre (), a government body in Brunei
 Pacific Symposium on Biocomputing, an annual scientific meeting
 Philippine Savings Bank
 Promsvyazbank, a Russian state-owned bank
 PS Business Parks, an American real estate investment trust (NYSE: PSB)
 PSB Insights, a market research firm (Penn Schoen Berland)
 Psychological Strategy Board, a U.S. government committee to coordinate psychological warfare
 Public security bureau (China), the name for a police department in mainland China
 Punjab & Sind Bank, Northern India (NSE: PSB)

Politics
 Belgian Socialist Party ()
 Brazilian Socialist Party ()
 Parti Sarawak Bersatu, a political party based in Malaysia
 United Sarawak Party, (), a political party in Sarawak, Malaysia

Science and medicine 
 Persistent slip bands
 Phosphate solubilizing bacteria
 Protected specimen brush
 Purple sulfur bacteria

Technology 
 Polysulfide–bromide battery
 Proton Synchrotron Booster, a synchrotron at CERN
 .PSB, an Abode Photoshop file format

Other 
 Mid-State Regional Airport (IATA airport code "PSB"), an airport in Philipsburg, Pennsylvania
 Polski Słownik Biograficzny, a Polish encyclopedia
 Poplar Street Bridge, a bridge across the Mississippi River
 Presidential Service Badge, of the US military
 Psychological Strategy Board, a committee set up by the Truman administration to coordinate and plan psychological operations
 Public service broadcasting in the United Kingdom
 Purple sprouting broccoli, a variety of broccoli