Α-L-fucosidase
{{DISPLAYTITLE:α-L-fucosidase}}

The enzyme α-L-fucosidase () catalyzes the following chemical reaction: an α-L-fucoside + H2O  L-fucose + an alcohol

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds.  The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase.  It participates in N-glycan degradation and glycan structure degradation.

Deficiency of this enzyme is called Fucosidosis.

In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

Human medical studies
It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children. This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

See also 
1,2-α-L-fucosidase
1,3-α-L-fucosidase
1,6-α-L-fucosidase
FUCA2

References

Further reading

External links 
 CAZy family GH29
 CAZy family GH95

Protein families
EC 3.2.1
Enzymes of known structure