Mother's Little Helpers
Mother's Little Helpers or Mother's Little Helper may refer to:

 Nickname for the drug Diazepam (Valium)
 Cougars, Inc., developed under the title Mother's Little Helpers, a 2010 indie film
 "Mother's Little Helper", a 1966 Rolling Stones song
 "Mother's Little Helper" (Medium), a 2007 Medium episode
 "Mother's Little Helper" (Once Upon a Time), a 2017 episode of Once Upon a Time
 "Mother's Little Helper", a Casualty episode
 "Mother's Little Helpers" (Helstrom), a 2020 Helstrom episode

See also
 "Brother's Little Helper", an episode of The Simpsons television series 
 Santa's Little Helper, a fictional dog from The Simpsons