Mast cell stabilizer
Mast cell stabilizers are medications used to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.

As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. Finally, in oral form, they are used to treat the rare condition of mastocytosis.

Examples
Mast cell stabilizer medications include:
 Cromoglicic acid (Cromolyn/cromoglycate)
 Lodoxamide
 Nedocromil

 Ketotifen
 Olopatadine
 Bepotastine
 Alcaftadine
 Azelastine

 Vitamin D

 β2-adrenergic agonists

References