The Mesta was a powerful association of sheep holders in the medieval Crown of Castile.

Mesta may also refer to:

People
 Perle Mesta (1889–1975), American society figure, political hostess, and ambassador to Luxembourg

Organizations
 Mesta (company), a Norwegian company primarily building roads
 Mesta Machinery, a former major US manufacturer of heavy machinery from 1898 until 1983, founded by George Mesta (1863–1925), the husband of Perle Mesta

Places
 Mesta River, a river in Bulgaria and Greece
 Mesta, Greece, a village on the island of Chios, Greece
 Mesta, Bulgaria, a village in Bulgaria

Other uses
 Mesta station, a light rail station in Pittsburgh, Pennsylvania, United States
 Imset or Mesta, in Egyptian mythology, a funerary deity, one of the Four sons of Horus
 Roselle (plant) or Meśta, a species of hibiscus native to the Old World tropics, cultivated for the production for bast fibre

See also
 Óláfs saga Tryggvasonar en mesta, one of the kings' sagas