Mozzanica (Bergamasque: ) is a comune (municipality) in the Province of Bergamo in the Italian region of Lombardy, located about  east of Milan and about  south of Bergamo.

Mozzanica borders the following municipalities: Caravaggio, Castel Gabbiano, Fara Olivana con Sola, Fornovo San Giovanni, Sergnano.

Mozzanica is the location of a Rohm and Haas plant. Located there is a  tall tower, built by Ludovico Sforza in 1492, on the nearby frontier with the Republic of Venice.

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