The 1925 Mississippi State Teachers Yellow Jackets football team was an American football team that represented the Mississippi State Teachers College (now known as the University of Southern Mississippi) as an independent during the 1925 college football season. In their second year under head coach William Herschel Bobo, the team compiled an 0–6 record.

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Mississippi State Teachers
Southern Miss Golden Eagles football seasons
College football winless seasons
Mississippi State Teachers Yellow Jackets football