Melandri is an Italian surname. Notable people with the surname include:

Francesca Melandri (born 1964), Italian novelist and filmmaker
Giovanna Melandri (born 1962), Italian politician
Lea Melandri (born 1941), Italian scholar and writer
Marco Melandri (born 1982), Italian MotoGP road racer

Italian-language surnames
it:Melandri