Toxica (Latin for toxic) may refer to:

 Melanodermatitis toxica lichenoides, an occupational dermatosis that occurs among tar handlers after several years' exposure
 Toxica (Power Rangers), a Power Rangers Wild Force character
 "La Tóxica", a song by Farruko from the 2021 album La 167
 Jessica Toxica, a character in the Mexican drama series Mujeres asesinas

See also