James Lee Woodruff (July 11, 1903 – November 21, 2007) was an American football player. 

Woodruff was born in 1903 in Johnson County, Nebraska. He grew up and attended high school in Hillsboro, Illinois. He attended the University of Illinois.

Woodruff played professional football in the National Football League (NFL) as an end and tackle for the Chicago Cardinals in 1926 and the Buffalo Bisons in 1929. He appeared in seven NFL games, five as a starter. He scored one touchdown during the 1929 season.

Woodruff died in 2007 in Tucson, Arizona.

References

1905 births
2007 deaths
American centenarians
Men centenarians
Pittsburgh Panthers football players
Chicago Cardinals players
Buffalo Bisons (NFL) players
Players of American football from Nebraska