Mark Hughes (born 1963) is a Welsh football manager and former international player.

Mark Hughes may also refer to:

Sports

Association football (soccer)
Mark Hughes (footballer, born 1962), Welsh football player for Tranmere
Mark Hughes (footballer, born 1983), Northern Ireland international football player
Mark Hughes (footballer, born 1986), English football player for Accrington Stanley
Mark Hughes (footballer, born 1993), Irish footballer

Other sports
Mark Hughes (rugby league, born 1954), English-born Australian rugby league footballer
Mark Hughes (basketball) (born 1966), American basketball player and coach
Mark Hughes (fighter) (born 1973), American mixed martial arts fighter
Mark Hughes (rugby league, born 1976), Australian rugby league footballer
Mark Hughes (journalist), English motorsports journalist
Mark Hughes (motorsport), British motorsport manager

Others
Mark Hughes (politician) (1932–1993), British politician; MP for Durham
Mark R. Hughes (1956–2000), American entrepreneur; founder of Herbalife
Mark Hughes (Emmerdale), fictional character on the ITV soap opera Emmerdale