Miss Caroline: The Little Girl in the Big White House  was a comic strip about a fictionalized version of Caroline Kennedy, the daughter of John F. Kennedy, who at the time was five years old. Editor & Publisher noted that the heads of Caroline's parents were never shown on panel.

Written by Gerald Gardner and drawn by Frank B. Johnson, the strip was published in newspapers beginning on November 4, 1963, and was abruptly cancelled following the assassination of Caroline's father on November 22.

The strip was launched to capitalize on the commercial success of Gardner and Johnson's book of cartoons Miss Caroline, which was published in January 1963 by Gold Medal Books, and sold 250,000 copies by July of that year.

Collections
In 2012, About Comics announced that they would be reprinting the complete Miss Caroline.

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American comic strips
Gag-a-day comics
Gag cartoon comics
Satirical comics
1963 comics debuts
1963 comics endings
Female characters in comics
Child characters in comics
White House in fiction
Comics set in Washington, D.C.
Comic strips based on real people
Comics characters introduced in 1963
Cultural depictions of John F. Kennedy