Calfee may refer to:

Carolyn Calfee (born 1974), American intensive care physician
Jack Calfee (1941–2011), American economist and author
Kent Calfee (born 1949), American politician
Robert C. Calfee (1933–2014), American educational psychologist

Calfee Design, California designer and manufacturer of carbon fiber bicycle frames by Craig Calfee
Calfee Park, a stadium in Pulaski, Virginia, used primarily for baseball
Calfee Nunatak, a geographical feature in Antarctica