Valguarnera may refer to:

Fabio Valguarnera, Italian wrestler
Filippo Valguarnera (born 1977), Italian legal scholar
Mariano Valguarnera (1564 – 1634), Italian philologist, historian and diplomat.
Valguarnera Caropepe, comune in Sicily, Italy
Palazzo Valguarnera-Gangi, historic house in Palermo, Sicily, Italy