*  Exposure Controls/Personal Protection  *
Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE OLY IN A CHEMICAL FUME HOOD.
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
*  Product Identification  *
*  Composition/Information on Ingredients  *
Ingred Name:EMETINE DIHYDROCHLORIDE CRYSTALLINE
Code:F
*  Hazards Identification  *
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NOOSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF INHALED,
    SWALLOWED, OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN
    IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT. ADDITIONAL INFORMATION: WHE N INGESTED EMETINE
    PRODUCES NAUSEA AND VOMITING. INJECTION PRODUCES PAIN, MUSCLE
    STIFFNESS, NECROSIS, ABSCESS FORMATION. OTHER ADVERSE EFFECTS
    INCLUDED NAUSEA, VOMITING, DIARRHEA, DIZZINESS, HEADACHE, 
    URTICARIA, PURPURIC SKIN RASH. MATERIAL ACCUMULATES MAINLY IN THE
    LIVER BUT APPRECIABLE LEVELS ARE ALSO FOUND IN THE KIDNEY, SPLEEN
    AND LUNGS PERSISTING FOR SEVERAL MONTHS IN THESE TISSUES. PROLONGED
     ADMINISTRATION OR (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZ: LARGE DOSES MAY CAUSE LESIONS OF THE
    HEART, KIDNEYS, LIVER, GASTRO-INTESTINAL TRACT AND SKELETAL MUSCLE.
    SEVERE DEGENERATIVE MYOCARDITIS MAY OCCUR GIVING RISE TO SUDDEN
    CARDIAC FAILURE AND D EATH. OTHER SERIOUS CARDIOVASCULAR EFFECTS
    INCLUDE PRECORDIAL PAIN, DYSPNEA, TACHYCARDIA AND HYPOTENSION. ECG
    CHANGES INCLUDE T-WAVE INVERSION, PROLONGATION OF THE Q-T INTERVAL
    AND ST ELEVATION.
*  First Aid Measures  *
First Aid:EYES OR SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
    SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BRATHING GIVE
    ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN. REMOVE AND WASH CONTAMINATED CLOTHING PROMPTLY.
*  Fire Fighting Measures  *
Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER, WATER SPRAY.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
*  Accidental Release Measures  *
Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
    SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
    RAISING DUST.
*Handling and Storage  *
Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
    EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
    HIGHLY TOXIC. IRRITANT. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY
    PLACE.
*  Physical/Chemical Properties  *
Appearance and Odor:WHITE TO PALE-YELLOW POWDER.
*  Stability and Reactivity Data  *
Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY PRODUCE
    CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN OXIDES. HYDROGEN
    CHLORIDE GAS.
*  Toxicological Information*
    NERVE & (ECOL INFO)
*  Ecological Information  *
Ecological:DATA NOT YET AVAILABLE. --TOXIC INFO: SENSATION (SPASTIC
    PARALYSIS WITH/WITHOUT SENSORY CH); PERIPHERAL NERVE AND SENSATION
    (FLACCID PARALYSIS WITHOUT ANESTHESIA); BEHAVIORAL (HALLUCINATIONS,
    DISTORTE D PERCEPTIONS, MUSCLE WEAKNESS); CARDIAC (OTHER CHANGES);
    LUNGS, THORAX OR RESPIRATION (CHRONIC PULMONARY EDEMA OR
    CONGESTION, DYSPNAE); GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA,
    NAUSEA OR VOMITING,  OTHER CHANGES); NUTRITIONAL AND GROSS
    METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT GAIN). ONLY SELECTED
    REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
    PRESENTED HERE. SEE ACTUAL ENTRY  IN RTECS FOR COMPLETE
    INFORMATION.
*  Disposal Considerations  *
Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.
*  MSDS Transport Information  *
Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.
*  Regulatory Information  *
    VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN & IF SWALLOWED. R
    CASE OF ACCIDENT OR IF YOU FELL UN WELL, SEEK MEDICAL ADVICE
    DO NOT BREATHE DUST. S 7/9 KEEP CONTAINER TIGH TLY CLOSED AND IN
    WELL-VENTILATED PLACE. REVIEWS, STANDARDS, AND REGULATIONS: OEL-MAK
    EPA TSCA SECTI ON 8(B) CHEMIAL INVENTORY.
*  Other Information  *
