*  Exposure Controls/Personal Protection  *
Respiratory Protection:A NIOSH APPROVED RESPIRATOR APPROPRIATE FOR THE
    EXPOSURE OF CONCERN .
Ventilation:USE WITH ADEQUATE VENTILATION. FOLLOW STANDARD MEDICAL
    PRODUCT HANDLING PROCEDURES.
    WASH HANDS AFTER REMOVING GL
Other Protective Equipment:EYEWASH & DELUGE SHOWER MEETING ANSI DESIGN
    CRITERIA . ROUTINE MEDICAL CLOTHING, SUCH AS LAB COAT, GOWN OR
    SMOCK SHOULD BE WORN WHEN PREPARING OR HANDLING THIS PRODUCT.
Work Hygienic Practices:PRODUCT PREPARATION INSTRUCTIONS FOR MEDICAL
    PERSONNEL: HANDLE MATL FOLLOWING STANDARD MEDICAL PRACTICES &
    FOLLOW RECOMMENDATIONS PRESENT ON PACKAGE INSERT.
Supplemental Safety and Health
AS WITH ALL CHEMICALS, AVOID GETTING MATL ON/IN YOU. WASH HANDS AFTER
    HANDLING. AVOID BREATHING SPRAYS/MISTS. DON'T EAT/DRINK WHILE
    HANDLING. WASH HANDS THOROUGHLY AFTER HANDLING
    PRODUCT/EQUIPMENT/CON TAINERS WHICH CONTAIN THIS PRODUCT. FOLLOW
    SPECIFIC USE INSTRUCTIONS SUPPLIED WITH THE PRODUCT.
*  Product Identification  *
Product ID:LEUCOVORIN CALCIUM INJECTION
*  Composition/Information on Ingredients  *
= Wt:1.
Other REC Limits:NE
OSHA PEL:NE
OSHA STEL:NE
ACGIH TLV:NE
ACGIH STEL:NE
Ingred Name:SODIUM CHLORIDE
< Wt:1.
Other REC Limits:NE
OSHA PEL:NE
OSHA STEL:NE
ACGIH TLV:NE
ACGIH STEL:NE
Ingred Name:WATER (FOR INJECTION)
Other REC Limits:NE
OSHA PEL:NE
OSHA STEL:NE
ACGIH TLV:NE
ACGIH STEL:NE
*  Hazards Identification  *
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NOOSHA:NO
Health Hazards Acute and Chronic:ACUTE: THE MOST SIGNIFICANT ROUTE OF
    EXPOSURE ANTICIPATED FOR THIS PRODUCT IS INJECTION. EXPOSURE TO
    THIS MATERIAL VIA INJECTION MAY CAUSE SYMPTOMS SIMILAR TO
    ALLERGIES: WHEALTS, REDNESS IN SKIN, POTE NTIALLY FATAL
    ANAPHYLACTOID REACTIONS. INGESTION MAY PRODUCE REACTIONS SIMILAR TO
    INJECTION. CONTACT W ITH SKIN OR EYES MAY LEAD TO IRRITATION OF
    EXPOSED TISSUE. THOUGH NOT DOCUMENTED, EXPOSURE TO THI S MATERIAL
    VIA OTHER ROUTES OF ENTRY MAY PRODUCE SYMPTOMS SIMILAR TO
    INJECTION. CHRONIC: LONG TERM EXPOSURE TO THIS PRODUCT MAY LEAD TO
    HYPERSENSITIZATION. THIS MATERIAL IS NOT KNOWN TO CAUSE CANCER O R
    ADVERSE REPRODUCTIVE EFFECTS.
Explanation of Carcinogenicity:THIS PRODUCT'S INGREDIENTS ARE NOT FOUND
    ON THE FOLLOWING LISTS: FEDERAL OSHA Z LIST, NTP, IARC, CAL OSHA.
Effects of Overexposure:THIS MATERIAL MAY BE HARMFUL IF INJECTED INTO
    SKIN. THE SOLUTION MAY BE IRRITATING TO THE EYES, SKIN, MUCOUS
    MEMBRANES AND OTHER TISSUES WHICH ARE CONTAMINATED. INHALATION:
    THERE IS NO EVIDENCE OF INH ALATION TOXICITY. THIS MUST BE
    CONSIDERED AS LACK OF SUFFICIENT TESTING RATHER THAN ABSENCE OF
    TOXICITY. BREATHING MISTS OR SPRAYS OF THIS MATL MAY IRRITATE
    RESPIRATORY TRACT. SKIN/EYES: NO EVIDENCE O F CONTACT TOXICITY.
    MUST BE CONS LACK OF SUFF TESTING RATHER THAN ABSENCE OF TOXICITY.
    BROKEN SKIN MAY ALLOW SUFFICIENT MATL TO ABSORB INTO BLOODSTREAM SO
    EXPOSED INDIVIDUAL CAN EXHIBIT TOXIC EFFECTS  SIMILAR TO INJECTION.
    (ECOLOGICAL INFO)
Medical Cond Aggravated by Exposure:NO KNOWN MEDICAL CONDITIONS ARE
    KNOWN TO BE AGGRAVATED BY ANTICIPATED OCCUPATIONAL EXPOSURES TO
    THIS PRODUCT.
*  First Aid Measures  *
First Aid:SKIN: IMMEDIATELY WASH AFFECTED AREA W/SOAP/WATER-RINSE
    CARE NOT TO CONTAM EYES. IF SPLASHED IN EYES, OPEN VICTIM'S EYES
    WHILE UNDER GEN TLE RUNNING H2*0. USE SUFFICIENT FORCE TO OPEN
    INHALED, REMOVE VICTIM TO FRESH AIR-USE ARTF RESP TO SUPPORT VITAL
    FUNCTIONS. REMOVE/COVE R GROSS CONTAM TO AVOID EXPOSURE TO
    RESCUERS. VICTIM & RESCUERS SHOULD OBTAIN MEDICAL ATTN, IF
    APPROPRIATE. NOTE TO PHYSICIANS: REFER TO ADVERSE REACTION INFO
    PROVIDED WITH PRODUCT. IF PRODUCT INGESTE D, RINSE (STATE REGS)
*  Fire Fighting Measures  *
Extinguishing Media:THE SIZE AND NATURE OF THIS PRODUCT IS SUCH THAT IT
    WILL NOT CONTRIBUTE TO THE INTENSITY OF A FIRE.  WATER SPRAY, FOAM,
    CARBON DIOXIDE, DRY CHEMICAL, HALON: OK.
Fire Fighting Procedures:FIREFIGHTING SHOULD BE AIMED AT SURROUNDING
    STRUCTURAL FIREFIGHTERS MUST WEAR (NIOSH APPROVED - )
    SELF-CONTAINED BREATHING APPARATU S AND  FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION, PRODUCT MAY
    EMIT TOXIC FUMES CONTAINING OXIDES OF NITROGEN AND CARBON MONOXIDE.
*  Accidental Release Measures  *
    OTHER APPROPRIATE MATLS. AVOID SPLASHING/SPRAYING LIQUID. RINSE
    AREA THOROUGHLY W/SOAP/WATE R. LARGE/UNCONTROLLED RELEASES (I.E.
    PRE-PLANNED PROCEDURES. PROPER PROTECTIVE EQUIPMENT SHOULD BE USED.
    IN CASE OF A SPILL, (SARA TITLE III)
*Handling and Storage  *
Handling and Storage Precautions:STORE PRODUCT IN ORIGINAL CONTAINER AT
Other Precautions:PROTECTIVE PRACTICES DURING MAINTENANCE OF
    CONTAMINATED EQUIPMENT: WHEN CLEANING NON-DISPOSABLE EQUIP, WEAR
    W/SOAP & WATER. ALL NEED LES, SYRINGES, VIALS & OTHER DISPOSABLE
    ITEMS CONTAMINATED BY PRODUCT SHOULD BE DISPOSED OF PROPERLY .
*  Physical/Chemical Properties  *
M.P/F.P Text:APPROX 0C
Vapor Pres:NOT AVAILABLE
Vapor Density:NOT AVAILA
Evaporation Rate & Reference:(WATER=1): APPROX 1.
Solubility in Water:COMPLETELY
Appearance and Odor:CLEAR, COLORLESS TO PALE YELLOW SOLUTION; ODORLESS.
*  Stability and Reactivity Data  *
Stability Indicator/Materials to Avoid:YES
THIS MATERIAL IS NOT COMPATIBLE WITH STRONG ACIDS, STRONG GASES, AND
    OXIDIZERS.HEAT MAY CAUSE PRODUCT TO DECOMPOSE, DESTROYING PRODUCT
    OR PRODUCING TOXIC FUMES (I.E., NITROGEN OXIDES AND CARBON
    MONOXIDE).
Stability Condition to Avoid:STABLE WHEN STORED UNDER AMBIENT CONDITONS
    UP TO SHELF LIFE. RECOMMENDED STORAGE TEMPERATURE IS APPROX. ROOM
Hazardous Decomposition Products:NITROGEN OXIDES AND CARBON MONOXIDE.
Conditions to Avoid Polymerization:HEAT AND CONTACT WITH INCOMPATIBLE
    CHEMICALS.
*  Toxicological Information*
    EXPOSURE: MAY BE IRRITATING TO THE SKIN.  INGESTION EXPOSURE:
    ALLERGIC REACTIONS MAY OCCUR.  INHA LATION EXPOSURE: NO REPORTED
    INHALATIONEFFECTS.IDLH [PPM] OSHA: LEUCOVORIN CALCIUM = NOT
    ESTABLISHED, SODIUM CHLORIDE = NOT ESTABLISHED, WATER (FOR
    INJECTION) = NOT ESTABLISHED.  RECOMMENDATIONS TO  PHYSICIANS:
    REFER TO ADVERSE REACTION INFORMATION PROVIDED WITH THE PRODUCT.
    WARNING PROPERTIES: THE SOLUTION HAS NO DISCERNIBLE WARNING
    PROPERTIES.
*  Ecological Information  *
Ecological:ENVIRONMENTAL STABILITY: BASED ON SIZE OF PRODUCT PACKAGING
    & SHIPPING METHOD, ENVIR IMPACT IS NOT EXPECTED.  EFFECT OF
    MATERIAL ON PLANTS & ANIMALS: NO ECOLOGICAL STUDIES ARE AVAILABLE. 
    EFFECT OF CH EM ON AQUATIC LIFE: NO INFO IS CURRENTLY AVAIL. SIGNS
    & SYMPTOMS (CONT): CONT W/ THE SOLUTION MAY BE IRRITATING TO THE
    EYES OR SKIN.  SKIN ABSORPTION: THERE IS CURRENTLY NO EVIDENCE THAT
    SKIN ABSORPTI ON IS A SIGNIFICANT ROUTE OF ENTRY.  INGESTION:
    POTENTIAL ALLERGIC REACTIONS, INCL ANAPHYLACTOID REACTIONS. 
    REACTION: ADVERSE REACTIONS TO LEUCOVORIN CALCIUM CONSISTS MAINLY
    OF ALLERGIC REACTIONS (I. E. SENSITIZATION, WHEALTS, ANAPHYIAXIS).
*  Disposal Considerations  *
Waste Disposal Methods:WASTE DISPOSAL MUST BE IAW APPROPRIATE FEDERAL,
    STATE & LOCAL REGULATIONS. THIS PRODUCT, IF UNALTERED BY HANDLING,
    MAY BE DISPOSED OF BY TREATMENT AT A PERMITTED FACILITY OR AS
    ADVISED BY YOUR LOCAL H AZARDOUS WASTE REGULATORY AUTHORITY. EPA
    WASTE NUMBER: NOT APPLICABLE.
*  MSDS Transport Information  *
    NAME: NOT APPLICABLE.  HAZARD CLASS NOUMBER AND DESCRIPTION: NOT
    APPLICABLE, UN ID N UMBER: NOT APPLICABLE, PACKING GROUP: NOT
    APPLICABLE, D.O.T. LABEL(S) REQUIRED: NOT APPLICABLE, EMERGENCY
    RESPONSE GUIDE NUMBER:NOT APPLICABLE, RQ: NOT APPLICABLE.
*  Regulatory Information  *
SARA Title III Information:N/P.   SPILL RELEASE PROCEDURES (CONT):
    CLEAR AFFECTED AREA, PROTECT PEOPLE. ABSORB SPILLED LIQUID
    W/POLYPADS/OTHER APPROP MATLS. AVOID SPLASHING/SPRAYING LIQUID.
    RINSE AREA THOROUGHLY WITH SOAP AND W ATER. PLACE RESIDUE IN DOUBLE
    PLASTIC BAG. DISPOSE OF IAW FEDERAL, STATE & LOCAL WASTE DISPOSAL
    REGULATIONS.   OTHER INFO (CONT): AND NITROGEN OXIDES UPON THERMAL
    DECOMPOSITION. IT POSES NO OTHER UNUS UAL EMERGENCY PROPERTIES.
Federal Regulatory Information:TSCA INVENTORY STATUS: THE COMPONENTS OF
    PRODUCT ARE LISTED ON THE TSCA INVENTORY.  MARINE POLLUTANT: THIS
    APPLICABLE.   LABELING (PRECAUTIONARY STATEMENTS): CAUTION! FEDERAL
    LAW PROHIBITS DISPENSING WITHOUT PRESCRIPTION. THIS MATERIAL MAY BE
    HARMFUL IF INJECTED INTO  SKIN OR INGESTED. INHALATION MAY ALSO BE
    HARMFUL. CONTACT WITH EYES MAY BE IRRITATING. AVOID BREATH ING
    SPRAYS AND MISTS. AVOID CONTACT WITH SKIN AND EYES. AVOID
    ACCIDENTAL INJECTIONS.
    PRODUCT ARE COVERED UNDER FOLLOWING SPECIFIC STATE REGULATIONS
    (NONE INDICATES NO SPECIALREGULATIONS WERE NOTED): AL, AK, CA,
    CT,DE, FL, IL, KS, ME, MD, MA, MI, MN, MO, MT, NH, NJ, NY, ND, OK,
    OR, PA, RI, TN, TX, VT, WA, WI, WV: NONE.FIRST AID (CONT):
    VICTIM'S MOUTH & CALL PHYSICIAN ORPOISON CONTROL CTR FOR MOST
    CURRENT INFO. IF PROF ADVICE IS NOT AVIAL, DO NOT INDUCE VOMITING.
    VICT IM(S) OF CONTAM W/ PRODUCT & ALL RESCUERS SHOULD GET MED ATTN,
    IF APPROP. TAKE COPY OF LABEL & MSDS TO PHYSICIAN OR HEALTH PROF
    WITH VICTIM.
*  Other Information  *
