*  Exposure Controls/Personal Protection  *
Respiratory Protection:WEAR APPROVED AIR-PURIFYING RESPIRATOR
    W/HIGH-EFFICIENCY CARTRIDGES WHEN APPLICABLE LIMITS ARE EXCEEDED.
Ventilation:USE CLOSED-SYSTEM HANDLING/LOCAL EXHAUST VENTILATION
    ADEQUATE TO CONTROL DUST/MIST.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. DESTROY CONTAMINATED LEATHER ITEMS.
Supplemental Safety and Health
EMERGENCY FIRST AID CONT'D: METHOTREXATE BLOOD LEVELS SHOULD BE
    MONITORED & THE CALCIUM LEUCOVORIN DOSE ADJUSTED ACCORDINGLY.
    COMPLETE HEMOGRAMS & LIVER & KIDNEY FUNCTION TESTS ARE RECOMMENDED.
*  Product Identification  *
CAGE:0P4V3
CAGE:0P4V3
*  Composition/Information on Ingredients  *
Fraction by Wt: 2.6%
*  Hazards Identification  *
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NOOSHA:NO
Health Hazards Acute and Chronic:METHOTREXATE- LEUKOPENIA,
    THROMBOCYTOPENIA, GI BLEEDING, BONE MARROW SUPPRESSION, LIVER
    DAMAGE, GI TRACT ABSORPTION, EFFECTS ON FERTILITY, MENSTRUAL
    DYSFUNCTION, HEMATOLOGIC CHANGES, SUPPRESSION OF IM MUNE SYSTEM,
    REDUCED LUNG DISEASE, CHROMOSOMAL CHANGES, ABNORMAL FETAL
    DEVELOPMENT, ABORTIONS. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:GI DISTURBANCES, NAUSEA, VOMITING, LOSS OF
    APETITE, DIARRHEA, CONGESTION OF THE LUNGS, COUGH
Medical Cond Aggravated by Exposure:PRE-EXISTING KIDNEY FUNCTION.
*  First Aid Measures  *
    PROMPTLY WASH W/SOAP & COOL RUNNING WATER. INHALATION: REMOVE TO
    FRESH AIR. GIVE CPR/OXYGEN IF NEEDED. INGESTION: INDUCE VOMITING AS
    DIRECTED B Y MEDICAL PERSONNEL. NEVER INDUCE VOMITING/GIVE ANYTHING
    BY MOUTH IF UNCONSCIOUS. OBTAIN MEDICAL ATTENTION IN ALL CASES.
    NOTE TO PHYSICIAN: CALCIUM LEUCOVORIN IS A NEUTRALIZER FOR
    METHOTREXATE.(SUPP)
*  Fire Fighting Measures  *
Unusual Fire/Explosion Hazard:METHOTREXATE DUST IS A CLASS 0 DUST
    EXPLOSION HAZARD.
*  Accidental Release Measures  *
    APPROVED SELF-CONTAINED/A SUPPLIED AIR RESPIRATOR, CONTAIN &
    COLLECT MATERIAL.
*Handling and Storage  *
Handling and Storage Precautions:MINIMIZE EXCESSIVE HANDLING.
    METHOTREXATE, A POTENT ANTI-CANCER DRUG, IS EXTREMELY TOXIC & MUST
    BE HANDLED W/GREAT CAUTION.
*  Physical/Chemical Properties  *
pH:8-8.9
Solubility in Water:INSOLUBLE
Appearance and Odor:CLEAR, YELLOW SOLUTION; PRESERVATIVE FREE; FREE
    FROM TURBIDITY.
*  Stability and Reactivity Data  *
Stability Indicator/Materials to Avoid:YES
ALKALINE SOLUTIONS
Hazardous Decomposition Products:CO, CO2, NITROGEN OXIDES, ALDEHYDES,
    KETONES, ORGANIC ACIDS, HYDROGEN CYANIDE
*  Disposal Considerations  *
Waste Disposal Methods:DISPOSE OF IAW/LOCAL, STATE & FEDERAL
    REGULATIONS. INCENERATION IS RECOMMENDED.
