*  Exposure Controls/Personal Protection  *
Respiratory Protection:TOXIC DUST RESPIRATOR OR AIRLINE MASK SHOULD BE
    USED IF MATERIAL IS RELEASED TO ATMOSPHERE.
Ventilation:AS NECESSARY TO REMOVE DUST. NOT NECESSARY IF MATERIAL IS
    CONTAINED IN VIALS. RECOMMEND USE OF HEPA FILTER.
Other Protective Equipment:PROTECTIVE OUTER CLOTHING, PREFERRABLY MADE
    OF DISPOSABLE MATERIAL, IS RECOMMENDED.
Work Hygienic Practices:MATERIAL SHOULD BE HANDLED IN A LAB HOOD
    WHENEVER POSSIBLE. HOOD SHOULD HAVE AN ABSOLUTE FILTER.
Supplemental Safety and Health
*  Product Identification  *
Product ID:L-ASPARAGINASE /ELSPAR/
*  Composition/Information on Ingredients  *
Ingred Name:L-ASPARAGINASE
Fraction by Wt: 6%
Ingred Name:MANNITOL
*  Hazards Identification  *
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NOOSHA:NO
Health Hazards Acute and Chronic:COMPOUND HAS BEEN SHOWN TO CAUSE BIRTH
    DEFECTS IN LAB ANIMALS WHEN GIVEN INTRAVENOUSLY AT DOSES IN
    THEAPEUTIC RANGE. NOT CONSIDERED A POTENTIAL OCCUPATIONAL HAZARD AS
    THE COMPLEX NATURE OF THE COMPOUN D'S STRUCTURE WOULD INHIBIT
    ABSORPTION.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:EYES AND SKIN: IRRITATION. INGESTION: NOT
    CONSIDERED A POTENTIAL ROUTE OF SYSTEMIC EXPOSURE. INHALATION:
    IRRITATION TO UPPER RESPIRATORY TRACT. SOME EXPOSED WORKERS HAVE
    EXPERIENCED CHILLS, FEVER, SLI GHT RESPIRATORY DISTRESS AND
    DIARRHEA.
*  First Aid Measures  *
    MINUTES. GET MEDICAL ATTENTION. SKIN: WASH IMMEDIATELY WITH SOAP
    AND WATER. INHALATION: REMOVE FROM EXPOSURE. GET MEDICAL ATTENTION
    IF SYMPTOM S APPEAR. INGESTION: DO NOT INDUCE VOMITING. DILUTE WITH
    WATER AND GET MEDICAL ATTENTION.
*  Fire Fighting Measures  *
Flash Point:NONE
Extinguishing Media:WATER SPRAY OR ALL PURPOSE DRY CHEMICAL TO FIGHT
    FIRES.
Fire Fighting Procedures:USE SELF-CONTAINED BREATHING APPARATUS AND
    PROTECT CLOTHING IF COMPOUND IS RELEASED DURING FIRE OR IS BURNING.
Unusual Fire/Explosion Hazard:NONE
*  Accidental Release Measures  *
Spill Release Procedures:VACUUM OR SWEEP UP SPILLED MATERIAL. AVOID
    CREATION OF AIRBORNE DUST. WEAR SUITABLE PROTECTIVE EQUIPMENT.
*Handling and Storage  *
Handling and Storage Precautions:MATL IS AN ENZYMATIC PROTEIN. SHOULD
Other Precautions:NONE
*  Physical/Chemical Properties  *
HCC:T6
Solubility in Water:COMPLETE
Appearance and Odor:WHITE LYOPHYLLIZED PLUG OR POWDER
*  Stability and Reactivity Data  *
Stability Indicator/Materials to Avoid:NO
Stability Condition to Avoid:OPEN CONTAINERS -AT RISK OF BACTERIAL
    CONTAMINATION
Hazardous Decomposition Products:NONE
*  Disposal Considerations  *
Waste Disposal Methods:IN ACCORDANCE WITH LOCAL, STATE, AND FEDERAL
    REGULATIONS. INCINERATION IS THE PREFERRED METHOD.
