The only other active players with 2,000+ strikeouts are Andy Pettitte at # 45 with 2,310 , CC Sabathia at # 58 with 2,140 , Kevin Millwood at # 61 with 2,059 and Roy Halladay at # 66 with 2,006.Career Strikeout Leaders , baseball-reference.comThe Top 10 Major League Baseball career strikeout-per-nine innings leaders ( since 1900 , through games of September 28 , 2011 , minimum 1,000 IP ) : Historical Leaders , K/9 at mlb.com , retrieved June 25 , 2012 # Randy Johnson – 10.61 # Kerry Wood – 10.32 # Pedro Martínez – 10.04 # Tim Lincecum - 9.87 # Nolan Ryan – 9.55 # Trevor Hoffman – 9.53 # Sandy Koufax – 9.28 # Oliver Perez – 9.12 # Sam McDowell – 8.86 # Johan Santana – 8.86The Top 5 Major League Baseball single season strikeout-per-nine innings leaders ( since 1900 , through games of June 25 , 2012 , minimum 1.0 IP per team game ) :
On August 10 , 2012 , Tim Lincecum had less than 9.85 strikeouts per nine innings , and Oliver Perez had less than 9.12 .