Three days later Varela made his first start and Champions League debut in the 2015–16 UEFA Champions League , playing the full 90 minutes in a 3–2 defeat to VfL Wolfsburg. Varela played at the 2013 FIFA U-20 World Cup , where the team finished as the runners-up , behind champions France.
Guillermo Varela played for the Uruguayian under-20 team at the 2013 FIFA U-20 World Cup .