The only other active players with 2,000+ strikeouts are Andy Pettitte at # 45 with 2,313 , CC Sabathia at # 54 with 2,197 , Kevin Millwood at # 59 with 2,083 and Roy Halladay at # 62 with 2,056.Career Strikeout Leaders , baseball-reference.comThe Top 10 Major League Baseball career strikeout-per-nine innings leaders ( since 1900 , through games of August 10 , 2012 , minimum 1,000 IP ) : Historical Leaders , K/9 at mlb.com , retrieved August 11 , 2012 # Randy Johnson – 10.61 # Kerry Wood – 10.32 # Pedro Martínez – 10.04 # Tim Lincecum - 9.81 # Nolan Ryan – 9.55 # Trevor Hoffman – 9.53 # Sandy Koufax – 9.28 # Oliver Perez – 9.11 # Sam McDowell – 8.86 # Johan Santana – 8.83The Top 5 Major League Baseball single season strikeout-per-nine innings leaders ( since 1900 , through games of June 25 , 2012 , minimum 1.0 IP per team game ) : # Randy Johnson , 2001 – 13.41
On September 24 , 2012 , Tim Lincecum , Trevor Hoffman , and Oliver Perez were among the historical players with the highest number of strikeouts per nine innings with under 9.8 , under 9.4 , and under 9.9 respectively .