Born in Montevideo , Varela started his career with his home-town club Peñarol and made his senior debut on 5 June 2011 , in a 1–0 home defeat against Racing Club de Montevideo on the last matchday of Uruguayan Primera División.=
Guillermo Varela was born in Lisbon and started his career in his home town club , Porto and made his senior debut against Rio Ave on the last matchday of Portuguese Primera División .