Johan Santana – 8.83The Top 5 Major League Baseball single season strikeout-per-nine innings leaders ( since 1900 , through games of September 26 , 2012 , minimum 1.0 IP per team game ) : # Randy Johnson , 2001 – 13.41
On September 26 , 2010 , Randy Johnson was one of the top 5 players with the highest number of strikeouts per nine innings in a season in Major League Baseball .