They both escape from the church after Osmund Saddler ( Michael Gough ) , leader of the Los Illuminados , reveals his plan to use the plaga they injected into Ashley to manipulate her into injecting the president of the United States with the `` sample '' ( a Master Plaga ) once she returns home , allowing Saddler to begin his conquest of the world .
In Resident Evil 4 , Osmund Saddler is the leader of the Los Illuminados .