 Pari gbolohun ti o tẹle: Ni ọrundun 21st, Wonder ṣe alabapin awọn orin tuntun meji si ohun orin fun Spike Lees Bamboozled awo-orin Awọn eniyan ti ko ni imọran ati Awọn ọdun diẹ sẹyin. Wonder n tẹsiwaju lati ṣe igbasilẹ ati ṣiṣe; botilẹjẹpe awọn ifarahan igbagbogbo ati awọn iṣẹ alejo, o ṣe awọn irin-ajo meji, o si ṣe igbasilẹ awo-orin kan ti ohun elo tuntun, A Time to Love ti ọdun 2005. Ní June 2006, Wonder ṣe àlejò nínú àwo orin Busta Rhymes The Big Bang, lórí orin Been through the Storm. O kọ orin atunbi ati kọ orin piano lori orin ti Dr. Dre ati Sha Money XL ṣe. Ó tún farahàn nínú orin tí ó kẹyìn nínú àwo orin Snoop Dogg Tha Blue Carpet Treatment, Conversations. Orin naa jẹ atunṣe ti Ṣe Ibaraẹnisọrọ pẹlu Ọlọrun lati Awọn orin ninu bọtini ti igbesi aye. Ni ọdun 2006, Wonder ṣe awokose pẹlu Andrea Bocelli lori awo-orin Amore ti igbehin, ti o nfun harmonica ati awọn ohun orin afikun lori Canzoni Stonate. Wonder tun ṣe ni Washington, D.C. 2006 A Capitol Fourth ayẹyẹ. Awọn ifarahan pataki rẹ pẹlu ṣiṣe ni ayẹyẹ ṣiṣi ti : 2002 Winter Paralympics in Salt Lake City, 2005 Live 8 concert in Philadelphia, the pre-game show for Super Bowl XL in 2006, the in 2009, and the opening ceremony of the 2011 Special Olympics World Summer Games in Athens, Greece. Àwọn eré ìdárayá Paralympics ìgbà òtútù ní Salt Lake City, àwọn eré ìdárayá Live 8 ní Philadelphia, àwọn eré ìdárayá tó ṣáájú Super Bowl XL ní 2006, àwọn eré ìdárayá Super Bowl XL ní 2009, àti ayẹyẹ ìbẹrẹ àwọn eré ìdárayá Special Olympics World Summer Games 2011 ní Athens, Greece. 