 Kọkọ parí gbólóhùn tó wà nísàlẹ yìí: Láti ọdún 1999 sí ọdún 2006, de Zegher ni olùdarí àgbà, olùtọjú ilé ìkóhun-ìṣẹǹbáyé, àti olóòtú ìwé The Drawing Center, ní New York. Labẹ itọsọna ọdun meje rẹ, ile-iṣẹ naa ṣafihan diẹ sii ju ọgọta awọn ifihan itan ati ti ode oni, faagun iwe-ipamọ ati eto ẹkọ rẹ, ati ṣẹda eto wiwo ti o pe awọn oṣere si awọn iṣẹ ọnà ti o da lori aworan ati awọn iṣe gbangba. Lati ọdun 2003 si 2005, o ṣe itọsọna awọn idunadura lati gbe Ile-iṣẹ iyaworan, ti o da ni SoHo, si Ground Zero gẹgẹbi apakan ti awọn ero lati pin ile kan pẹlu Ile-iṣẹ Ominira International ti a dabaa. Ise agbese naa jẹ apakan ti iranti fun awọn olufaragba, ati musiọmu kan ti a pinnu lati fa ifojusi si awọn ogun fun ominira jakejado itan ti a gbero lẹsẹkẹsẹ lẹhin awọn ikọlu ati : Ìparun Ilé Ìtajà Àgbáyé. Lẹyìn ìjà agbára tí ó bẹrẹ pẹlú ìyípadà sí Ground Zero, de Zegher fi ipò rẹ sílẹ ní oṣù kẹta ọdún 2006. Awọn iṣẹ akanṣe ti De Zegher ni The Drawing Center pẹlu Eva Hesse Drawing ni apapọ pẹlu Elisabeth Sussman ati Joelle Tuerlinckxs Drawing Inventory mejeeji ni ọdun 2006; Persistent Vestiges: Drawing from the American Vietnam War, ati 3 x Abstraction: Awọn ọna tuntun ti iyaworan nipasẹ Hilma af Klint, Emma Kunz, ati Agnes Martin, Richard Tuttle: O jẹ yara fun awọn eniyan 3 ni ọdun 2005; Ocean Flowers: Impressions from Nature pẹlu Carol Armstrong 2003-2004; Giuseppe Penone: The Imprint of Drawing 2004; Ipele ti iyaworan: Ige ati Iṣe. Ti a yan lati inu gbigba Tate  2003; Anna Maria Maiolino: A Life Line  Vida Afora  2002; Bracha Lichtenberg Ettinger: Eurydice Series , ati Laarin Street ati Mirror: Awọn aworan ti James Ensor meji ni ọdun 2001; Untitled Passages by Henri Michaux  ti o ṣe alabapin pẹlu Florian Rodari ati The Prinzhorn Collection: Traces Upon the Wunderblock ni ifowosowopo pẹlu Inge Jadi ati Laurent Busine mejeeji ni ọdun 2000. 