 Ekwunife don kontest fo Anambra governorship election two taim but shi no win. Dem elekt Ekwunife fo 2007 to represent Anambras AnaochaNjikokaDunukofia constituency. Shi bi one of 11 women wey dem elekt fo 2007, wey dem still re-elekt fo 2011 wen di lower haus almost bi  95 men.Oda women wey dem elekt na Juliet Akano, Mulikat Adeola-Akande, Abike Dabiri, Nkiru Onyeagocha, Nnena Elendu-Ukeje, Olajumoke Okoya-Thomas, Beni Lar, Khadija Bukar Abba-Ibrahim, Elizabeth Ogbaga and Peace Uzoamaka Nnaji. Fo 2015, dem elekt ha to Nigerian Senate. Shi bi one of the six women wey den elekt to the 8th Nashonal Assembly. The orda women na Rose Okoji Oko, Stella Oduah, Fatimat Raji Rasaki, Oluremi Tinubu and Binta Garba. Na as Ekwunife move from one politikal Pati to another one na im shi tek win. Bicos dem chalenj di elektshon fo Dizemba 2015 dem kom declare ha seat vacant. As Ekwunife no get di suppot of former politikal party The All Progressives Grand Alliance fo di bye-elekshon, na Victor Umeh dem kom  elect as Senator. Shi win di 2019 Anambra State senatorial elekshon under the platform of di Peoples Democratic Party wey represent Anambra central Senatorial District, Nigeria. 