 Complete the following phrase:  Qaitbays death in 1496 was followed by a violent interregnum. This coincided with other developments in the region and beyond, including the discovery of gold in the New World, and Portugals penetration into the Indian Ocean, placing it on collision course with Mamluk Egypt. And with the onset of the Italian Wars, Spains interest in Egypt and the eastern Mediterranean began to decline, with the focus shifting towards strengthening its positions in the western Mediterranean to be able to challenge the French presence in Italy. The civil war in Egypt concluded with the ascent to power of Sultan Qansuh al-Ghuri, who now ruled over a weakened state that was under constant threat of invasion by its militarily superior Ottoman rival. By this time, the Catholic Monarchs had used 