 Complete the following phrase:  Following the peopling of Africa some 130,000 years ago, and the recent Out-of-Africa expansion some 70,000 to 50,000 years ago, some sub-populations of Homo sapiens have been geographically isolated for tens of thousands of years prior to the early modern Age of Discovery. Combined with archaic admixture, this has resulted in significant genetic variation, which in some instances has been shown to be the result of directional selection taking place over the past 15,000 years, which is significantly later than possible archaic admixture events. That the human populations living on different parts of the globe have been evolving on divergent trajectories reflects the different conditions of their habitats. Selection pressures were especially severe for populations affected by the Last Glacial Maximum LGM in Eurasia, and for sedentary 