When james was climbing he experiences a couple of symptoms. The most painful and long lasting was on his hands.  What might have happened to him?\nOptions:\n- calluses\n- loss of oxygen\n- vertigo\n- ascending\n- blisters Hmmm, let me think.
User
Blisters can happen on hands. Blisters are a symptom. Blisters are painful and long-lasting.
So, the answer is blisters.
Assistant