 Knuttila and Loettgers (2014) examine the role of analogical reasoning in synthetic biology, an interdisciplinary field that draws on physics, chemistry, biology, engineering and computational science. The main role for analogies in this field is not the construction of individual analogical arguments but rather the development of concepts such as “noise” and “feedback loops”. Such concepts undergo constant refinement, guided by both positive and negative analogies to their analogues in engineered and physical systems. Analogical reasoning here is “transient, heterogeneous, and programmatic” (87). Negative analogies, seen as problematic obstacles for individual analogical arguments, take on a prominent and constructive role when the focus is theoretical construction and concept refinement.