 This kind of mechanism was immediately interpreted as providing answers to the question how different genes become activated at different times and in different tissues during metazoan development (differential gene expression). Between the 1950s and the 1980s the concept of specific developmental genes emerged (Morange 2001: Ch. 7). Developmental biologists identified a limited number of genes that were essential in establishing the organization of the very early embryo and functioned by controlling the expression of various other genes. Molecular cloning led to the molecular characterization of developmental genes and the discovery of their evolutionary conservation (Weber 2004, see also the entry on   developmental biology).