 A different motivation drives neurobiologist Alcino Silva, neuroinformaticist Anthony Landreth, and philosopher of neuroscience John Bickle’s (2014) focus on experimentation. All contemporary sciences are growing at a vertiginous pace; but perhaps none more so than neuroscience. It is no longer possible for any single scientist to keep up with all the relevant published literature in even his or her narrow research field, or fully to comprehend its implications. An overall lack of clarity and consensus about what is known, what remains doubtful, and what has been disproven creates special problems for experiment planning. There is a recognized and urgent need to develop strategies and tools to address these problems. Toward this explicit end, Silva, Landreth, and Bickle’s book describes a framework and a set of principles for organizing the published record. They derive their framework and principles directly from landmark case studies from the influential neuroscientific field of molecular and cellular cognition (MCC), and describe how their framework can be used to generate maps of experimental findings. Scientists armed with these research maps can then determine more efficiently what has been accomplished in their fields, and where the knowledge gaps still reside. The technology needed to automate the generation of these maps already exists. Silva, Landreth, and Bickle sketch the transformative, revolutionary impact these maps can have on current science.