 Reynolds distinguishes two fundamental classes of metaphors: cells as human artifacts and cells as organisms. Each has taken on a variety of more specific forms. Among artifacts, cells have been characterized as spaces enclosed by solid walls, building blocks, factories, various types of machines, and electronic computers. The organismal metaphors have suggested a conceptualization of cells as elementary organisms (like unicellular amoebae) or citizens in a state or society in which there is a division of labor and in which cells make decisions that determine their own developmental ‘fates’, including the ultimate decision to initiate programmed cell death (Reynolds  2014).[1]  These metaphors have given rise to distinctive research agendas that focus on specific aspects of cells and their relationship to other cells and their environment.