 In addition to antigen/receptor dynamics, other factors are also involved in delineating the scope of tolerable changes in the organism. These include a self-regulated system of diverse interactions among several immune components comprising a complex system of antigen-presenting cells, effector T and B lymphocytes, regulatory cells and a diverse soup of molecular signals (Kim, Levy, and Lee 2009; Kidd et al. 2014). So, the functional difference that determines recognition of the foreign results not only from an aggregate of quantitative ligand-receptor affinity differences, but also from the context in which the antigen is seen and the degree of interruption in network dynamics induced by such an immunogen (Cohen 2000a; Cohen and Efroni 2019). Accordingly, the overall function of the immune system may be defined as maintenance of molecular (antigenic) homeostasis (Poletaev, Stepanyuk, and Gershwin 2008). On this general view, a systems-wide collective response—not the discriminatory power of individual lymphocytes or their receptors—determines identity and immune specificity.