 Against the universalism of explanatory laws, Cartwright has argued that laws cannot be both universal and true, as Hempel required in his influential account of explanation and demarcation; there exist only patchworks of laws and local cooperation. Like Dupré, Cartwright adopts a kind of scientific realism but denies that there is a universal order, whether represented by a theory of everything or a corresponding a priori metaphysical principle (Cartwright 1983). The empirical evidence, she argues, along the same lines as Wimsatt, suggests far more strongly the idea of a dappled world, best represented by a patchwork of laws, often in local cooperation (e.g., local identifications, causal interactions, joint actions and piecemeal corrections and correlations). Theories apply only where and to the extent that their interpretive models fit the phenomena studied (Cartwright 1999). But this is not their alleged universal factual scope. They only hold in special conditions like ceteris paribus. Cartwright’s pluralism is not just opposed to vertical reductionism but also horizontal imperialism, or universalism and globalism. She explains their more or less general domain of application in terms of causal capacities and arrangements she calls nomological machines (Cartwright 1989; Cartwright 1999). The regularities they bring about depend on a shielded environment. As a matter of empiricism, this is the reason that it is in the controlled environment of laboratories and experiments, where causal interference is shielded off, that factual regularities are manifested. The controlled, stable regular world is an engineered world. Representation rests on intervention (comp. Hacking 1983). On these grounds, as a matter of holism Cartwright rejects strong distinctions between natural and social sciences, and like Otto Neurath, between the natural and the social world. Whether as a hypothesis or as an ideal, the debates continue over the form, scope and significance of unification in the sciences. Cartwright’s theses and arguments rest on numerous assumptions that have been target of insightful criticism (Winsberg et al. 200,; Hoefer 2003, Sklar 2003, Howhy 2003, Teller 2004, McArthur 2006 and Ruphy 2016).