 Various kinds of regulatory regions in DNA are spread throughout most genomes. They comprise “non-coding” sequences, in the sense that they do not code for proteins and do not depend on the genetic code. Regulatory regions affect gene expression and chromatin dynamics. It is still debated in the scientific community whether there are general properties of sequence organization that determine these functions, which would suggest a high-order code. It should be noted that various non-coding sequences interact in specific ways with epigenetic mechanisms (such as DNA methylation and histone modifications) in order to produce their regulatory effects. The genome which is the seat of genetic information is also a focal point for the operation of critical epigenetic mechanisms, and it may turn out not to be possible to fully understand the properties of the genetic inheritance system and its evolution in isolation from epigenetic inheritance (Jablonka &amp; Lamb 2008; Lamm 2011, 2014).