 The current shift to whole-genome sequencing will also help to address another critique of the GWAS/SNP/HapMap approach, namely its strict focus on single base pair changes in the genome. Other changes in the genome, such as variations in the numbers of copies of repeated elements or rearrangements, deletions or insertions of larger chunks of genomic DNA, might in many cases be what is at the core of a disorder, necessitating (again) a shift in focus away from point mutations and single genes to the genome as a whole (Lupski 1998, 2009).