 The tendency of natural science toward progressive independence from metaphysics in the eighteenth century is correlated with this point about method. The rise of modern science in the sixteenth and seventeenth centuries proceeds through its separation from the presuppositions, doctrines and methodology of theology; natural science in the eighteenth century proceeds to separate itself from metaphysics as well. Newton proves the capacity of natural science to succeed independently of a priori, clear and certain first principles. The characteristic Enlightenment suspicion of all allegedly authoritative claims the validity of which is obscure, which is directed first of all against religious dogmas, extends to the claims of metaphysics as well. While there are significant Enlightenment thinkers who are metaphysicians – again, one thinks of Christian Wolff – the general thrust of Enlightenment thought is anti-metaphysical.