 In December 1723 Collins’ only son suddenly became ill and died. His father was grief-stricken. Collins remarried in 1724 and he published what is perhaps his most successful book, A Discourse on the Grounds and Reasons of the Christian Religion as well as An Historical and Critical Essay on the Thirty Nine Articles of the Church of England. From 1725 until 1729 Collins’ health began to deteriorate. Still, in 1726 he published The Scheme of Literal Prophecy Considered. In 1729 Collins published A Discourse Concerning Ridicule and Irony in Writing. He was suffering from gall stones and finally died of his disease on December 13, 1729. His second wife Elisabeth and his two daughters survived him. He willed his unpublished manuscripts to Pierre Desmaizeaux but Desmaizeaux took an offer from Collins’ widow to buy them. Desmaizeaux quickly regretted his decision, but it was too late. He accused Elisabeth Collins of giving some of Collins unpublished papers to the Bishop of Lincoln. She denied that the story was true. She willed some or all of Collins unpublished papers to a friend. What became of them is still a mystery.