 In managing and communicating about reproductive risk, we face several challenges. First and perhaps most obviously, while pregnant women and fetuses are inextricably physically intertwined, the risks and potential benefits to each of them of various actions, situations, and interventions are typically different and can even be in tension. Managing risk can be especially complicated and ethically charged given this entwinement of two different sets of risks and potential benefits. Second, as will be discussed below, there are various reasons why good-quality evidence about reproductive risk is hard to come by, and hence we often must make decisions about how to manage such risk under a great deal of uncertainty. Third, features of our cultural context can distort our perceptions of reproductive risk (Drabble et al. 2011). Such distortions become ethically relevant to the extent that they either lead us to decisions that are not, as they purport to be, in the best interests of babies or their mothers, or that place inappropriate burdens and responsibilities on pregnant women that are not responsive to reality. The following sections survey some ethical issues that highlight these barriers to high-quality reasoning about reproductive risk.