The overall picture envisaged by the teleosemantic approach has undeniably appealing structural features. If this program succeeds, we would have an uncontroversial sense of information, via Shannon, that applies to all sorts of physical correlations. This picture can then be developed by identifying a subset of cases in which these signals have been co-opted or produced to drive biological processes. In addition, perhaps we can appeal to rich semantic properties in cases where we have the right kind of history of natural selection to explain the distinctive role of genes, and perhaps other factors, in development.  Genes and a handful of non-genetic factors would have these properties; most environmental features that have a causal role in biological development would not. There remain many problems of detail, but the appeal of the overall picture provides, at least for some, good reason to persevere with some account along these lines.