 An important approach in visual neuroscience was articulated by A.J. Parker and William Newsome in “Sense and the Single Neuron” (1998) via “principles” to connect electrophysiological data about information processing to perception (for a recent discussion, see Ruff &amp; Cohen 2014). To probe the neural basis of perception, neuroscientists need to explanatorily link neural data to the subject’s perception that guides behavior. The experimenter must ensure that recorded neural content correlates with perceptual content and not just response. Further, manipulation of the neurons carrying information should affect perception: inducing appropriate neural activity should shift perceptual response while abolishing or reducing that activity should eliminate or reduce perceptual response as measured in behavior. These proposals address concerns about necessity and sufficiency.