 When the process of producing data is relatively convoluted, it is even easier to see that human sense perception is not the ultimate epistemic engine. Consider functional magnetic resonance images (fMRI) of the brain decorated with colors to indicate magnitudes of electrical activity in different regions during the performance of a cognitive task. To produce these images, brief magnetic pulses are applied to the subject’s brain. The magnetic force coordinates the precessions of protons in hemoglobin and other bodily stuffs to make them emit radio signals strong enough for the equipment to respond to. When the magnetic force is relaxed, the signals from protons in highly oxygenated hemoglobin deteriorate at a detectably different rate than signals from blood that carries less oxygen. Elaborate algorithms are applied to radio signal records to estimate blood oxygen levels at the places from which the signals are calculated to have originated. There is good reason to believe that blood flowing just downstream from spiking neurons carries appreciably more oxygen than blood in the vicinity of resting neurons. Assumptions about the relevant spatial and temporal relations are used to estimate levels of electrical activity in small regions of the brain corresponding to pixels in the finished image. The results of all of these computations are used to assign the appropriate colors to pixels in a computer generated image of the brain. In view of all of this, functional brain imaging differs, e.g., from looking and seeing, photographing, and measuring with a thermometer or a galvanometer in ways that make it uninformative to call it observation. And similarly for many other methods scientists use to produce non-perceptual evidence.