Moral philosophy has a long history of making normative appeals to human nature. There are thorny philosophical issues about whether such appeals are ever legitimate. Even since David Hume warned us not to derive an “ought” from an “is”, philosophers have been wary of making strong inferences about what ought to be done directly from claims about human nature. However, the tradition of virtue ethics is much more comfortable with adopting a naturalistic approach that holds that human nature is the basis for what constitutes human well-being and the virtues (for human beings) (Fitzgerald 2008; Keenan 1999). Explaining what is worth cherishing about being human is an intuitive starting point for making sense of ourselves, our relationships with other human beings, and the world around us. The task of getting clear about what we do and should value about being human has important implications for the ethics of biomedical enhancements.