 Finally, naïve HD can be enriched by the appeal to explanation. Here, the naïve HD clause for confirmation is meant to be too weak because \(h\wedge k\) must be able (not only to entail, but) to explain \(e\). By this move, the HD approach embeds the slogan of the so-called inference to the best explanation view: “observations support the hypothesis precisely because it would explain them” (Lipton 2000, 185; also see Lipton 2004). Historically, the main source for this connection between explanation and support is found in the work of Charles Sanders Peirce (1839–1914). Janssen (2003) offers a particularly neat contemporary exhibit, explicitly aimed at “curing cases of the Duhem-Quine disease” (484; also see Thagard 1978, and Douven 2017 for a relevant survey). Quite unlike eliminativist approaches, explanationist analyses tend to focus on large-scale theories and relatively high-level kinds of evidence. Dealing with Einstein’s general relativity, for instance, Janssen (2003) greatly emphasizes its explanation of the equivalence of inertial and gravitational mass (essentially a brute fact in Newtonian physics) over the resolution of the puzzle of Mercury’s perihelion. Explanationist accounts are also distinctively well-equipped to address inference patterns from non-experimental sciences (Cleland 2011). 