 Del Medigo’s most distinct metaphysical work is his De ente et essentia et uno, composed following his conversations with Pico on being, essence and unity, siding with Averroes against Avicenna (Montada 2013: 163–64). Yet the lengthiest of all Del Medigo’s original composition is the Two Investigations on the Nature of the Human Soul, a work on Aristotelian psychology which concentrates on the nature and destiny of the human intellect.