 The other possibility is to reject its second premise. However, if physicalism can be clearly stated — admittedly, this is a big ‘if’ — it is not terribly clear what this would amount to or what the motivation for it would be. In the first place, our earlier discussion shows that physicalism is not inconsistent with explanatory autonomy of the various sciences, so that one should not reject physicalism merely because one can’t see how to reduce those sciences to others. In the second place, while it is perfectly true that there are examples of non-physicalist approaches to the world — vitalism in biology is perhaps the best example — this is beside the point. The second premise of the Argument from Methodological Naturalism does not deny that other views are possible, it simply says that physicalism is the most likely view at the moment. Finally, one might be inclined to appeal to arguments such as the knowledge argument to show that physicalism is false, and hence that methodological naturalism could not show that physicalism is false. However, this suggestion represents a sort of confusion about the knowledge argument. As we saw above, if successful the knowledge argument suggests, not simply that physicalism is false but that any approach to the world that is compatible with methodological naturalism is false. But if that is so, it is mistaken to suppose that the knowledge argument gives one any reason to endorse anti-physicalism if that is supposed to be a position compatible with methodological naturalism.