 Thus, a successful search for new elementary particles critically depends on successfully crafting selection criteria and techniques at the stage of data collection and at the stage of data analysis. But gradual development and changes in data selection procedures in the colliders raises an important epistemological concern. The main reason for this concern is nicely anticipated by the following question, which was posed by one of the most prominent experimentalists in particle physics: “What is the extent to which we are negating the discovery potential of very-high-energy proton machines by the necessity of rejecting, a priori, the events we cannot afford to record?” (Panofsky 1994, 133). In other words, how does one decide which interactions to detect and analyze in a multitude, in order to minimize the possibility of throwing out novel and unexplored ones?