 These philosophical criticisms of manipulability theories contrasts with the widespread view among statisticians, theorists of experimental design, and many social and natural scientists that an appreciation of the connection between causation and manipulation can play an important role in clarifying the meaning of causal claims and understanding their distinctive features. This in turn generates a puzzle. Are non-philosophers simply mistaken in thinking that focusing on the connection between causation and manipulation can tell us something valuable about causation? Does the widespread invocation of something like a manipulability conception among practicing scientists show that the usual philosophical criticisms of manipulability theories of causation are misguided?