 Unlike DNA-based device construction and genome-driven cell engineering, synthetic biologists in the practice of protocell creation engage in classical theoretical discussions on what life is, and how it originated and evolved (Luisi 2006; O’Malley et al. 2008). This research stream connects to discussions of the fundamental properties of life in systems biology (Cornish-Bowden 2006; Letelier et al. 2011; Wolkenhauer and Hofmeyr 2007) and philosophy (Bich 2010; Bich &amp; Damiano 2007; Bedau &amp; Cleland 2010; Moreno &amp; Mossio 2015).