 The multiverse response replaces a single, apparently finely-tuned universe within an ensemble of universes, combined with an appeal to anthropic selection. Suppose that all possible values of the fundamental constants are realized in individual elements of the ensemble. Many of these universes will be inhospitable to life. In calculating the probabilities that we observe specific values of the fundamental constants, we need only consider the subset of universe compatible with the existence of complexity (or some more specific feature associated with life). If we have some way of assigning probabilities over the ensemble, we could then calculate the probability associated with our measured values. These calculations will resolve the fine-tuning puzzles if they show that we observe typical values for a complex (or life-permitting) universe.