 In this era dedicated to human progress, the advancement of the natural sciences is regarded as the main exemplification of, and fuel for, such progress. Isaac Newton’s epochal accomplishment in his Principia Mathematica (1687), which, very briefly described, consists in the comprehension of a diversity of physical phenomena – in particular the motions of heavenly bodies, together with the motions of sublunary bodies – in few relatively simple, universally applicable, mathematical laws, was a great stimulus to the intellectual activity of the eighteenth century and served as a model and inspiration for the researches of a number of Enlightenment thinkers. Newton’s system strongly encourages the Enlightenment conception of nature as an orderly domain governed by strict mathematical-dynamical laws and the conception of ourselves as capable of knowing those laws and of plumbing the secrets of nature through the exercise of our unaided faculties. – The conception of nature, and of how we know it, changes significantly with the rise of modern science. It belongs centrally to the agenda of Enlightenment philosophy to contribute to the new knowledge of nature, and to provide a metaphysical framework within which to place and interpret this new knowledge.