 The “informational gene” conception, as James R. Griesemer (2005) terms it, is a highly abstract concept of a process and the entities that comprise it. This is intentional, as it permits Darwinian dynamics to be applied to a range of phenomena, such as sociocultural, cybernetic, and medical processes. However, this raises a metaphysical concern, namely that the view that a gene is nothing but information is a version of Aristotelian hylomorphism [see the entry  form versus matter].  That is, information is a type of form, which can be used to explain physical processes. Classical hylomorphism was roundly demolished as a scientific hypothesis when Daltonian elements were named and investigated in the nineteenth century. By 1900, terms like “substance” (for matter that is propertyless apart from mass and extension in space) and “form” had taken on a largely philosophical sense that differed extensively from Aristotle’s own physical views. Griesemer notes: