 According to the whole-brain standard, human death is the irreversible cessation of functioning of the entire brain, including the brainstem. This standard is generally associated with an organismic definition of death (as explained below). Unlike the older cardiopulmonary standard, the whole-brain standard assigns significance to the difference between assisted and unassisted respiration. A mechanical respirator can enable breathing, and thereby circulation, in a “brain-dead” patient—a patient whose entire brain is irreversibly nonfunctional. But such a patient necessarily lacks the capacity for unassisted respiration. On the old view, such a patient counted as alive so long as respiration of any sort (assisted or unassisted) occurred. But on the whole-brain account, such a patient is dead. The present approach also maintains that someone in a permanent (irreversible) vegetative state is alive because a functioning brainstem enables spontaneous respiration and circulation as well as certain primitive  reflexes.[1]