 Example 8  (Morphine and meperidine). In 1934, the pharmacologist Schaumann was testing synthetic compounds for their anti-spasmodic effect. These drugs had a chemical structure similar to morphine. He observed that one of the compounds—meperidine, also known as Demerol—had a physical effect on mice that was previously observed only with morphine: it induced an S-shaped tail curvature. By analogy, he conjectured that the drug might also share morphine’s narcotic effects. Testing on rats, rabbits, dogs and eventually humans showed that meperidine, like morphine, was an effective pain-killer (Lembeck 1989: 11; Reynolds and Randall 1975: 273).