 In the network schema, cognition is not of something; perception is entirely within the system itself; the agent has vanished, and with that vacancy, representations are discarded (Vaz and Varela 1978: 238; Mingers 1991; Coutinho 2003; Palacios and Bacigalupo 2003; Vaz 2011a). After all, what requires a re-presentation? In Jerne’s system, no hierarchy exists, and no cognitive center corresponding to company headquarters. Instead, what heretofore was referred to as activation resulting from a subject-object predicate structured cognitive event (described by stimulus-response language) now refers to increased dynamic activity that is due to the disruption of the network’s equilibrium. Accordingly, immune “knowledge” shifts from a signifier–signified relationship to one in which meaning is firmly lodged within the system itself. Simply, the subject-object epistemological structure of cognition has been radically revamped.