 Here is an overview of the entry: Section 1 surveys the independence results in cardinal arithmetic, covering both the case of regular cardinals (where CH lies) and singular cardinals. Section 2 considers approaches to CH where one successively verifies a hierarchy of approximations to CH, each of which is an “effective” version of CH. This approach led to the remarkable discovery of Woodin that it is possible (in the presence of large cardinals) to have an effective failure of CH, thereby showing, that the effective failure of CH is as intractable (with respect to large cardinal axioms) as CH itself. Section 3 continues with the developments that stemmed from this discovery. The centerpiece of the discussion is the discovery of a “canonical” model in which CH fails. This formed the basis of a network of results that was collectively presented by Woodin as a case for the failure of CH. To present this case in the most streamlined form we introduce the strong logic Ω-logic. Section 4 takes up the competing foundational view that there is no solution to CH. This view is sharpened in terms of the generic multiverse conception of truth and that view is then scrutinized. Section 5 continues the assessment of the case for ¬CH by investigating a parallel case for CH. In the remaining two sections we turn to the global approach to new axioms and here we shall be much briefer. Section 6 discusses the approach through inner model theory. Section 7 discusses the approach through quasi-large cardinal axioms. 