 How do monist views handle the other forms of inheritance that are known to exist? Consider the mitochondria. Monist accounts regard the maternal inheritance of organelles such as the mitochondria, which might conceivably be thought to constitute a separate inheritance channel, if not system, to be of marginal conceptual importance. First, it can be argued that being based on genetically coded information (DNA sequence), the similarities with nuclear inheritance allows it to be seen as not involving a distinct inheritance system, if this notion is understood to refer to the way hereditary information is stored and transmitted. Indeed, views that focus on multiple inheritance systems may, for the very same reason, not consider the inheritance of plastids as based on a distinct inheritance system. Second, it is assumed that the evolution of complex organismal traits is to be explained by natural selection acting on variation in genetic information in the nucleus. Thus, mitchondrial inheritance, and plastid inheritance more generally, are considered to be of limited explanatory value when trying to give a general account of the evolution of the organism (beyond the early stages of endosymbiogenesis), and is of interest mainly when considering the evolution of the mitochonrdia themselves, in which case there is yet again a single inheritance system that is relevant, that of the mitochondrial genome. Similar reasoning is applied more generally to reject forms of supposedly extra-genetic inheritance that are not based on the transmission of DNA, by claiming either that the inheritance fails to be the transmission of information or that the information that can be transmitted is limited and thus not evolutionarily significant, and is merely the transmission of material resources or infrastructure. Cashed out in the terms of the replicator framework, arguments against supposed cases of extra-genetic inheritance are that they do not lead to the establishment of replicators, which are entities that are faithfully copied and passed down multiple generations, yet replicators are necessary for evolution by natural selection, or that extra-genetic inheritance leads to replicators that are limited in the repertoire of variants they support (see Godfrey-Smith 2000). Proponents of the multiple inheritance systems view and of holistic views about inheritance argue that these requirements are either unnecessary or too strong, and lead to a distorted understanding of evolution (see Griffiths &amp; Gray 2001; Jablonka 2001).