 One such indirect criticism of the HapMap derives from the apparent failure of GWAS to lead researchers to clearer information about the links between our genetic makeup and the different conditions to which our bodies can succumb. In the eyes of these critics the CD/CV hypothesis was the key problem, as the common variants simply do not explain much of the heritability of common diseases. This observation gave rise to the concept of ‘missing heritability’ (Eichler et al. 2010).