  Response 1. There is nothing implausible or new about such constraints. For instance, if the universe is spatially closed, there has to be enough matter to produce the needed curvature, and this puts constraints on the matter distribution on a space-like hypersurface. Thus global space-time structure can quite unproblematically constrain matter distributions on space-like hypersurfaces in it. Moreover we have no realistic idea what these constraints look like, so we hardly can be said to have evidence that they do not obtain.