 Loosely understood, moreover, distresses such as these are an inescapable part of the human condition and a normal response to life’s vicissitudes. When and whether normal (and even appropriate) suffering reflects pathology has long been the source of philosophical—and societal—disagreement (Wilkinson 2000; Horwitz &amp; Wakefield 2007). In the discussions of “normal sadness” that accompanied the revision of a fifth edition of the DSM, the grief exclusion that had (temporarily) exempted from diagnosis the suffering around mourning and grief, was challenged, its proposed elimination charged with “medicalizing” or “pathologizing” normal and appropriate human feelings (Zachar 2014; Wakefield 2012). We might expect the separation of normal from pathological distress and, more broadly, the characterization of mental disorder in terms of distress, to be indicated by distress emanating from the disorder itself, rather than from other contingencies. But equally outcomes of the disorder itself are the distresses resulting from the stigma and discrimination that follow diagnosis and treatment, as well as a host of other, frequently negative, consequences in jarring and alarming disruptions to personal lives, selves, and relationships (Tekin 2011).