 The theoretically inclined affective neuroscientist Kent Berridge has for decades influentially argued that mesolimbic dopamine itself gives no true pleasure, but that a core neural basis for a state of ‘liking’ involved in conscious pleasure is mediated by other brain activity, including some involving opioid receptors and sometimes cannabinoid receptors as well. These seem to be involved in organizing the circuit and network activity that makes possible the savoring more prominent in the consummatory, satisfying, and relaxing phases of meals, sexual activity, and personal relations and, so far as we know, all other pleasure and enjoyment as well, even as mesolimbic dopamine ’wanting’ seems typically more prominent in the earlier and more exploratory, appetitive, instrumental, and approach phases of these. Berridge and his collaborators persuasively argue that without the participation of localized hedonic ’hotspot’ activity there is no true pleasure, with specific transmitter activity in these small areas always required. While so far as is known such results may apply with generality, the preponderance of evidence as of yet comes from invasive experiments on rodents, and therefore relies on expressive and voluntary behavior to indicate pleasure. (See Berridge references and his website linked below for new review articles, Kringelbach references, papers in their jointly edited 2010. For a complementary perspective on relevant opioid systems, see Depue and Morrone-Strupinksy 2005, especially §6.1.2, pp. 323–25). The emerging picture seems not one of ’pleasure centers’ or ’pleasure transmitters’ but of diverse neurons capable of behaving flexibly, in different modes, and thus able to collectively self-organize into different circuits and different networks with changing input and neuromodulation, some of which differences make the differences between feeling happy, so-so, or sad. But we must remember that this science is still very much a work in progress and that the picture is growing more, not less, complex at this time. 