 A common argument in favor of treating genetic inheritance as having a unique developmental role is the claim that genes play an informational role, not shared by other hereditary developmental resources. The holistic view of inheritance articulated by Developmental Systems Theory downplays the significance of the idea that inheritance should be conceived as the transmission of information between generations (Griffiths &amp; Gray 2001; Sterelny 2001: 334, see also the discussion in Sterelny et al. 1996: 379). In particular, DST uses the so-called parity argument to reject the view that DNA is uniquely informational while other inherited resources merely provide material support for reading or interpreting DNA (Griffiths &amp; Knight 1998). In recent work Griffiths applies an information-theoretic measure of causal specificity to measure how a given factor contributes to the precise determination of the phenotype. This measure is produced by combining the classic notion of mutual information, as found in Shannon information theory, with Woodward’s notion of speficity of causes (Woodward 2010). Griffiths (2017) argues that this framework naturally extends to various epigenetic marks and non-coding regions of DNA that are causally specific, while at the same time distinguishing these cases from many other causes of the same outcomes, such as the presence of RNA polymerase, that lack such specificity.