 In particular, such questionable research practices (QRP) increase the type I error rate, which measures the rate at which false hypotheses are accepted, substantially over its nominal 5% level and contribute to publication bias (Bakker et al. 2012). Ioannidis (2005) concludes that “most published research findings are false”—they are the combined result of a low base rate of effective causal interventions, the file drawer effect and the widespread presence of questionable research practices. The frequentist logic of hypothesis testing aggravates the problem because it provides a framework where all these biases can easily enter (Ziliak and McCloskey 2008; Sprenger 2016). These radical conclusions are also confirmed by empirical findings: in many disciplines researchers fail to replicate findings by other scientific teams. See  section 5.1  for more detail.