 Critics and defenders of Rosenberg’s view have discussed organizational and contextual features not captured by molecular biological principles. These included orientation of the embryo in the earth’s gravitational field and other spatial, regulatory, and dynamical properties of developing systems (e.g., see Delehanty 2005; Frost-Arnold 2004; Keller 1999; Laubichler and Wagner 2001; Love et al. 2008; Robert 2001, 2004). This particular debate can be understood as an instance of a more general debate occurring in biology and philosophy of biology about whether investigations of lower-level molecular biology are better than investigations of high-level systems biology (Baetu 2012a; Bechtel and Abrahamsen 2010; De Backer, De Waele, and Van Speybroeck 2010; Huettemann and Love 2011; Marco 2012; Morange 2008; Pigliucci 2013; Powell and Dupre 2009; see also the entries on  feminist philosophy of biology,  philosophy of systems and synthetic biology, and  multiple realizability).