 Three goals motivate Silva, Landreth, and Bickle’s approach. First, they derive their framework from the cellular and molecular neurobiology of learning and memory. This choice was due strictly to familiarity with the science. Silva was instrumental in bringing gene targeting techniques applied to mammals into behavioral neuroscience, and Bickle’s focus on ruthlessly reductive neuroscience was built on these and other experimental results. And while each of their framework’s different kinds of experiments and evidence have been recognized by others, theirs purports to be the first to systematize this information explicitly toward the goal of facilitating experimental planning by practicing scientists. Silva, Landreth and Bickle insist that important new experiments can be identified and planned by methodically filling in the different forms of evidence recognized by their framework, and applying the different forms of experiments to the gaps in the experimental record revealed by this process.