 The fact that little can be learned from data without causal, statistical, and related argumentation has interesting consequences for received ideas about how the use of observational evidence distinguishes science from pseudoscience, religion, and other non-scientific cognitive endeavors. First, scientists are not the only ones who use observational evidence to support their claims; astrologers and medical quacks use them too. To find epistemically significant differences, one must carefully consider what sorts of data they use, where it comes from, and how it is employed. The virtues of scientific as opposed to non-scientific theory evaluations depend not only on its reliance on empirical data, but also on how the data are produced, analyzed and interpreted to draw conclusions against which theories can be evaluated. Secondly, it does not take many examples to refute the notion that adherence to a single, universally applicable ‘scientific method’ differentiates the sciences from the non-sciences. Data are produced, and used in far too many different ways to treat informatively as instances of any single method. Thirdly, it is usually, if not always, impossible for investigators to draw conclusions to test theories against observational data without explicit or implicit reliance on theoretical resources.