 ESB can be considered a meeting ground not only for systems biology and evolutionary biology but also for the integrated study of developmental phenomena in an evolutionary perspective (O’Malley et al. 2015). Systems biology complements statistical sequence analysis in population genetics and studies of constraints on evolutionary pathways in Evolutionary Developmental biology (EvoDevo) through in silico modelling of large data-sets (Jaeger &amp; Crombach 2012; Kim et al. 2011; see also Brigandt 2015). Some projects also draw on synthetic modelling of intracellular networks to investigate how the evolutionary potential of a lineage is affected by specific combinations of mutations (Palmer &amp; Kishony 2013).