  It turns out that in many cases this is the only known way to compare ZFC+φ and ZFC+ψ, that is, in many cases there is no direct interpretation in either direction, instead one must   pass through the large cardinal axioms.  Can this additional feature be used to make a case for large cardinal axioms?  The answer is unclear.  However, what is clear is the absolute centrality of large cardinal axioms in set theory.