 Alongside such varying and frequently conflicting normative uses of the expression “human nature”, there are serious disagreements concerning the concept’s content and explanatory significance—the starkest being whether the expression “human nature” refers to anything at all. Some reasons given for saying there is no human nature are anthropological, grounded in views concerning the relationship between natural and cultural features of human life. Other reasons given are biological, deriving from the character of the human species as, like other species, an essentially historical product of evolution. Whether these reasons justify the claim that there is no human nature depends, at least in part, on what it is exactly that the expression is supposed to be picking out. Many contemporary proposals differ significantly in their answers to this question.