 Ultimately, this is part and parcel of Lotze’s overarching strategy of driving a wedge between scientific fact, on the one hand, and human significance, meaning and value, on the other: science, to which falls the task of describing what is, can never provide us with the ultimate meaning of or reason behind what is. Lotze remained convinced that no value theory could be derived from science and that, yet, the teleological impulse was intrinsic to and irreplaceable in human existence. On more than one occasion, he avers to the following line of reasoning: