 Explanations in developmental biology are usually causal, though unlike standard mechanistic explanation there is a constant acquisition of new causal capacities (in terms of constituent entities, activities, and their organization) through development (McManus 2012; Parkkinen 2014). Although much work remains in characterizing different aspects of explanation in developmental biology, there is no doubt that a difference making or manipulability conception of causation (see the entry on  causation and manipulability)  provides a core element of the reasoning (Woodward 2003; Strevens 2009; Waters 2007a). Genetic explanations of development  (Section 3.1),  similar to what is seen in  molecular genetics,  work by identifying changes in the expression of genes and interactions among their RNA and protein products that lead to changes in the properties of morphological features during ontogeny (e.g., shape or size), while holding a variety of contextual variables fixed. More recently, there has been growing interest in physical explanations of development  (Section 3.2)  that involve appeals to mechanical forces due to geometrical arrangements of mesoscale materials, such as fluid flow (Forgacs and Newman 2005). Researchers agree on the phenomena that need to be explained  (Section 1.2  and  Section 2.2),  but differ on whether physical rules or genetic factors are more or less explanatory (Keller  2002).[8]  The existence of two different types of causal explanations for developmental phenomena poses an additional question about how they might be combined into a more integrated explanatory framework  (Section 3.3).