  Soto and Sonnenschein would likely reject this analysis, insofar as their argument was not simply that tissue organization is deserving of our attention, for pragmatic reasons, but “that carcinogenesis resulted from the disruption of the reciprocal interactions between stroma and epithelium.” Or more precisely, “the cancer phenotype is an emergent phenomenon occurring at the tissue level of organization” (2006, p. 371). What evidence is offered up for this kind of causal relationship? There are three sources of evidence that Soto and Sonnenschein have emphasized as of relevance to their defense of “organicism” and TOFT: