 Pomponazzi contended that fields such as astrology and physiognomy read signs that are causally connected through celestial influences or physiological links. Celestial prodigies, omens, and apparitions in the sky both signal and cause future events by affecting vapors and spirits that in turn influence the outcomes of human activity. Some apparitions, such as the recent image of Saint Celestine that appeared in the sky above Aquila while its residents prayed for protection from excessive rain, result from the collective imagination affecting vapors, exhalations, and clouds (see Giglioni 2010). Moreover, Pomponazzi argued that the prodigies’ indicative character explains their purpose and final cause that is linked to nature, which is interdependent, well ordered, and under God’s providence. The possibility of using prodigies to predict the future is analogous to physicians’ ability to give prognoses for diseases using symptoms that seemingly are not directly connected to the maladies. Similarly ignorant people have mistakenly understood the prognostications of sibyls and other seers as being caused by demons when in fact they possess either extraordinary occult natural powers or are caused by astral powers.