 It makes no sense to treat different answers as competitors if they are answering different questions. We have reviewed a framework of four questions with which the debates appearing under the rubric of “units of selection” can be classified and clarified. The original discussants of the units of selection problem separated the classic question about the level of selection or interaction (the interactor question) from the issue of how large a chunk of the genome functions as a replicating unit (the replicator question). The interactor question should also be separated from the question of which entity should be seen as acquiring adaptations as a result of the selection process (the manifestor-of-adaptation question). In addition, there is a crucial ambiguity in the meaning of adaptation that is routinely ignored in these debates: adaptation as a selection product and adaptation as an engineering design. Finally, we can distinguish the issue of the entity that ultimately benefits from the selection process (the beneficiary question) from the other three questions.