 However, we should not forget the master-builders that Locke mentions at the beginning of the Essay. Stephen Gaukroger (2010) claims that Locke’s great achievement was to provide a philosophical justification for the kind of experimental philosophy that Boyle’s work on the air pump, and his and Newton’s work on colors, as well as Sydenham’s observational medicine. All of these had been attacked for not providing explanations in terms of matter theory. Thus, Locke is justifying the autonomy of experimental philosophy. Such experimental explanations depend solely on the relation between phenomena, even when there is some micro-corpuscular basis for the phenomena being explained. According to Gaukroger, this is Locke’s contribution to the collapse of mechanism. For the details of the problem and its solution, see Chapters 4 and 5 of Gaukroger (2010).