 Pereira’s epistemology follows from a theory of the soul whose basic premises are simplicity and indivisibility (González Vila 1975: 22). His own vision of the rational soul led him to object to the philosophy of Aristotle, as well as to give a response to the question of whether the human intellect can perform its own activity without the support of the body. Pereira’s reply was a categorical yes: in fact, given his own epistemological premises, knowledge is possible only if it is identical with the substance of the soul itself. To demonstrate this assertion, the author addressed some issues that had been present in the debate about the nature and destiny of the soul from the Middle Ages (see Nardi 1958: 365–442; Kristeller 1979: 181–196; Valverde 2019: 35–55).