 Skepticism enjoys a remarkably strong place in Enlightenment philosophy, given that confidence in our intellectual capacities to achieve systematic knowledge of nature is a leading characteristic of the age. This oddity is at least softened by the point that much skepticism in the Enlightenment is merely methodological, a tool meant to serve science, rather than a position embraced on its own account. The instrumental role for skepticism is exemplified prominently in Descartes’ Meditations on First Philosophy (1641), in which Descartes employs radical skeptical doubt to attack prejudices derived from learning and from sense experience and to search out principles known with certainty which may serve as a secure foundation for a new system of knowledge. Given the negative, critical, suspicious attitude of the Enlightenment towards doctrines traditionally regarded as well founded, it is not surprising that Enlightenment thinkers employ skeptical tropes (drawn from the ancient skeptical tradition) to attack traditional dogmas in science, metaphysics and religion.