  In November 1641, however, Regius initiated a new series of disputations, De illustribus aliquot quaestionibus physiologicis (Regius 1641b), in which he challenged Aristotelian theses that were taught by his colleagues in philosophy and theology at the University. This attracted a very negative response from Voetius, who relied on Aristotelian philosophy to articulate his version of Calvinist theology. The resulting lengthy controversy, during which Regius lost the support of Descartes while simultaneously continuing the conflict with Voetius, is discussed below. He published the first edition of his book on natural philosophy under the title Fundamenta physices (1646); Chapter XII, entitled De homine (Regius 1646, 245–306), provided a synoptic exposition of his controversial views about human nature.