 A measure of caution is in order. “Skeptic” is an ancient Greek term meaning inquirer. The Academics did not use it of themselves; The descriptive appellation ‘skeptic[al] ’ was first applied by Pyrrhonians to their school in order to signal their commitment to open-minded inquiry (see the overview in the entry on  ancient skepticism). Understood in this way, the term applies at least as well to the skeptical Academy as to the Pyrrhonian school, which was founded or revived by Aenesidemus, an Academic who reacted against what he saw as an increasingly dogmatic tendency in the Academy of his time in the first century B.C.E. Later in antiquity the term “skeptic” seems to have been applied to both schools.  A range of arguments that, in one way or another, call the existence or possibility of knowledge into question, together with the positions or attitudes taken in response to, or expressed by, these arguments, have been styled “skeptical”, and several forms of skepticism were defended by different Academics in the course of the school’s history.