However, while this framework very naturally fits within cell and between cell processes, it is much less clear how naturally other suggestions mesh with this framework. For example, in the Bergstrom-Rosvall picture of intergenerational transmission, who or what are the senders and receivers? Perhaps in the case of multicelled organisms, the receiver exists independently of and prior to the message. For an egg is a complex and highly structured system, before gene expression begins in the fertilised nucleus, and that structure plays an important role in guiding that gene expression (Sterelny 2009; Gilbert 2013). But most organisms are single celled prokaryotes, and when they fission, it is not obvious that there is a daughter who exists prior to and independently of the intergenerational genetic message she is to receive.