 Recent debate has challenged the mutual manipulability account (Leuridan 2012, Harinen 2018, Romero 2015). One issue is that inter-level experiments are necessarily “fat-handed” (Baumgartner and Gebharter 2016) because they change the values of at least two different variables residing at different levels (e.g., calcium binding and synaptic transmission, where the former is a part of the latter). But this threatens to undermine the inferences to mechanistic constitution. A possible solution might consist in inferring constituents abductively, by positing constitutive relations as the best explanation for the presence of common causes that unbreakably correlate phenomena and their constituents (Baumgartner and Casini 2017).