 Closely related with natural selection, the issue of evolution is approached from very different perspectives. For instance, Guillemo Folguera stresses the dependence of macroevolution on microevolution even in the criticisms of the synthesis since the seventies (Folguera and Lombardi 2012), and Maurizio Esposito (2011) supplies examples of how Darwinism was used and adapted in different contexts. But the most extensive work on this issue has been developed by Edna Suárez-Díaz who focused specifically on molecular evolution. In this field, she studied the role played by the concept of informational molecule and by the idea of molecular evolution of informational molecules in differentiating molecular from classical evolutionists and in the constitution of genomics (Suárez-Díaz 2009, 2010). Despite stressing the importance of the molecular experimental approach in evolutionary biology (Suárez-Díaz and Barahona 1996), Suárez-Díaz acknowledges the methodological and conceptual difficulties embedded in the use of molecular evidence to elaborate molecular phylogenies (Suárez-Díaz and Anaya-Muñoz 2008; Suárez-Díaz 2014a), and emphasizes the generative nature of experimentation (Suárez-Díaz 2013).