 Fundamental physics encompasses two successful theories, General Relativity (GR) and Quantum Field Theory (QFT), that are mutually inconsistent. In recent years, a number of Quantum Gravity theories have been put forward as candidate deeper theories that can account for core dynamical principles and successful predictions of both theories within one consistent framework. Strikingly, in almost all such theories, spacetime is not part of the fundamental ontology, it being supplanted by a framework that lacks at least some of its structure. Many theorists say that the spacetime of GR is thereby rendered emergent. Its dependence is reflected in how the many roles that spacetime plays in GR and the spatiotemporally structured experimental observations themselves (and indeed, ubiquitous perceptions of everyday life!) are grounded in nonspatiotemporal structures in the proposed fundamental theories. Its autonomy takes the form of nonfundamental spacetime’s being qualitatively different from any feature of the fundamental theory.