 It used to be common for philosophers to argue that there is empirical reason to believe that the world in general is causally determined, and since human beings are parts of the world, they are too. Many took this to be strongly confirmed by the spectacular success of Isaac Newton’s framework for understanding the universe as governed everywhere by fairly simple, exceptionless laws of motion. But the quantum revolution of the early twentieth century has made that ‘clockwork universe’ image at least doubtful at the level of basic physics. While quantum mechanics has proven spectacularly successful as a framework for making precise and accurate predictions of certain observable phenomena, its implications for the causal structure of reality is still not well understood, and there are competing indeterministic and deterministic interpretations. See the entry on  quantum mechanics  for detailed discussion.) It is possible that indeterminacy on the small-scale, supposing it to be genuine, ‘cancels out’ at the macroscopic scale of birds and buildings and people, so that behavior at this scale is virtually deterministic. But this idea, once common, is now being challenged empirically, even at the level of basic biology. Furthermore, the social, biological, and medical sciences, too, are rife with merely statistical generalizations. Plainly, the jury is out on all these inter-theoretic questions. But that is just a way to say that current science does not decisively support the idea that everything we do is pre-determined by the past, and ultimately by the distant past, wholly out of our control. For discussion, see Balaguer (2009), Koch (2009), Roskies (2014), Ellis (2016).