  Maddy presents some serious objections to the first premise of the indispensability argument (Maddy 1992; 1995; 1997). In particular, she suggests that we ought not have ontological commitment to all the entities indispensable to our best scientific theories. Her objections draw attention to problems of reconciling naturalism with confirmational holism. In particular, she points out how a holistic view of scientific theories has problems explaining the legitimacy of certain aspects of scientific and mathematical practices. Practices which, presumably, ought to be legitimate given the high regard for scientific practice that naturalism recommends. It is important to appreciate that her objections, for the most part, are concerned with methodological consequences of accepting the Quinean doctrines of naturalism and holism — the doctrines used to support the first premise. The first premise is thus called into question by undermining its support.