 Mill’s methods can be formalized and generalized into rich and sophisticated methodologies of causal reasoning (e.g., Ragin 1987, Baumgartner 2009, Graßhoff 2011, Beirlaen, Leuridan and Van De Putte 2018). Such accounts haven been successfully used in the reconstruction of historical episodes such as the discovery of the urea cycle (Graßhoff, Casties and Nickelsen 2000; Grasshoff and May 1995).