 Meaning is ontologically rooted in our individual experience of the world and thus irreducible: The reason scientific theories eliminate most semantic aspects of our world, is caused by the very nature of methodology of science itself. The essence of meaning and the associated emotions is that they are rooted in our individual experience of the world. By focusing on repeated observations of similar events by different observers scientific methodology excludes the possibility of an analysis of the concept of meaning a priori. Empirical scientific methodology is valuable in the sense that it allows us to abstract from the individual differences of conscious observers, but there is no reason to reduce our ontology to the phenomena studied by empirical science. Isolated individual events and observations are by definition not open to experimental analysis and this seems to be the point of demarcation between science and the humanities. In disciplines like history, literature, visual art and ethics we predominantly analyze individual events and individual objects. The closer these are to our individual existence, the more meaning they have for us. There is no reason to doubt the fact that sentences like “Guernica is a masterpiece that shows the atrocities of war” or “McEnroe played such an inspired match that he deserved to win” uttered in the right context convey meaningful information. The view that this information content ultimately should be understood in terms of computational processes seems too extreme to be viable. 