 What neuroscience has now discovered about the cellular and molecular mechanisms of neural conductance and transmission is spectacular. These results constitute one of the crowning achievements of scientific inquiry. (For those in doubt, simply peruse for five minutes a recent volume of Society for Neuroscience Abstracts.) Less comprehensive, yet still spectacular, are discoveries at “higher” levels of neuroscience: circuits, networks, and systems. All this is a natural outcome of increasing scientific specialization. We develop the technology, the experimental techniques, and ultimately the experimental results-driven theories within specific disciplines to push forward our understanding. Still, a crucial aspect of the total picture sometimes gets neglected: the relationship between the levels, the “glue” that binds knowledge of neuron activity to subcellular and molecular mechanisms “below”, and to circuit, network, and systems activity patterns “above”. This problem is especially glaring when we try to relate “cognitivist” psychological theories, postulating information-bearing representations and processes operating over their contents, to neuronal activities. “Co-evolution” between these explanatory levels still seems more a distant dream than an operative methodology guiding day-to-day scientific research.