 As a result of computational models and analyses of large networks, cell biology in the twenty-first century is much more focused on organization and appears much less reductionistic than it did in the mid twentieth century. For some philosophers, this reliance on network analyses represents a move away from mechanistic explanations towards a process view (Théry 2015; Nicholson 2018; Dupré 2012). Huneman (2010, 2018) construes the explanations resulting from network analysis as a distinct type of explanation he labels topological explanation. Others, however, argue that since these analyses still draw upon the components constituting the system and the biologists developing them continue to think of them as mechanistic, we should extend the conception of mechanistic explanation to include the holistic focus on organization developed in computational and network analyses (Baetu 2015; Bechtel 2015; Levy 2014).