 Reference to the scientific method has also often been used to argue for the scientific nature or special status of a particular activity. Philosophical positions that argue for a simple and unique scientific method as a criterion of demarcation, such as Popperian falsification, have often attracted practitioners who felt that they had a need to defend their domain of practice. For example, references to conjectures and refutation as the scientific method are abundant in much of the literature on complementary and alternative medicine (CAM)—alongside the competing position that CAM, as an alternative to conventional biomedicine, needs to develop its own methodology different from that of science.