 The observational studies had picked up a true signal for the women closer to menopause. In the randomised trial, that signal was diluted because fewer women close to menopause were enrolled… The randomised trials had it right for coronary heart disease but failed to sufficiently focus on women close to menopause for breast cancer. The main reasons for the discrepancies were changes of the effects of HRT over different times… (Vandenbroucke 2009: 1234)