 This is simply false. While it is true that these questions have been manifested with differing frequency and vigor through history, and the ability to answer them (as well as the nature of the questions themselves) has been contingent on different research strategies and methods, the issue has not been an unwieldy central problem. But scrutinizing the structure of developmental biology’s questions is not merely an exercise in clarification. It is crucial for understanding how the science of developmental biology is organized.