 There are philosophical disputes happening at the heart of the biomedical enterprise and those disputes offer a means of understanding the epistemological dimensions of biomedicine: the nature of evidence and knowledge in the framework. The most contentious of those internal biomedicine disputes center on what the epistemology of biomedicine ought to be, with the rise of “evidence-based medicine” (EBM) being the event that provoked the largest segment of these disputes. By examining the disputes surrounding EBM, we can gain a better understanding of the epistemology of biomedicine, as illustrated in work such as Solomon’s Making Medical Knowledge (2015).