 In spring of 1524 Agrippa moved to Lyon to take up the office of physician to the French king’s mother, Louise of Savoy. He tried to win the favor of the king’s sister, Marguerite d’Alençon, by dedicating to her his declamation De sacramento matrimonii (On the Sacrament of Marriage, 1526) in parallel Latin and French versions. Unfortunately, it was a blunder and a terrible failure. The princess (who had recently been widowed) was already hostile to the Erasmian ‘spirit’, which Agrippa referred to in order to claim the lawfulness and benefit of second marriages. Furthermore, ecclesiastical authorities were able to recognize the influence of some Erasmus’ condemned works on Agrippa’s positive attitude towards marriage, as well as the link which connected it to the treatise De sacro coniugio (On Holy Wedlock) of the Franciscan François Lambert, who had fled to Strasbourg after joining the Reformation. Agrippa’s position at court was becoming worse. His friendships, his sympathies for the work of humanist Reformers, his more and more aggressive theses—in 1526 he reworked an earlier oration or letter, Dehortatio gentilis theologiae (Dissuasion from Pagan Theology), in which he criticized contemporaries for their excessive curiosity about Hermetic theology and their disregard for Christian education—were raising doubts his religious orthodoxy. His correspondence with the Duke of Bourbon, who had betrayed the French Crown in order to side with the Emperor, called into question his political loyalties, and he was suspected of involvement in a plot. His refusal to furnish an astrological prognostication for François I and his incautious remarks about Louise’s superstition, which a friend passed on to her, sparked off her open hostility. Agrippa was stripped of his pension and forbidden to leave France. In the midst of such dramatic misadventures, he wrote his De incertitudine et vanitate scientiarum. It was a biting commentary on all human sciences and arts and a fierce attack on the moral and social assumptions of his day. Agrippa subjected the work to later revisions and enlargements, right up to the moment of publication, in 1530.