  Neumann-Held points out that if the aim is to specify what is necessary for regulated synthesis of polypeptides, then one must include even more than what is located in the DNA. This follows from the fact that processes such as differential splicing (and RNA editing processes such as methylation that I have not discussed in this article) involve entities outside of DNA such as splicing agents.  She suggests that it is appropriate, at least in the context of developmental genetics, to reconceive genes as processes. She proposes the following process molecular gene concept.