Of course, the line between biomedical and other enhancements is often blurry. Caffeine is a drug that can heighten alertness, but coffee drinking is a social practice outside the biomedical sphere. Meditation and prayer can have the same physiological effects as drugs.  The “cyborgs” of science fiction blend human bodies with electronic and mechanical tools (Hughes 2004). The prospect of uploading minds into computers to create bodiless human life is sometimes characterized as “radical enhancement” (Agar 2013). But as important and intriguing as these mixed cases are from ethical and conceptual perspectives (Hogle 2005), this essay will only engage them in two ways. The first is when they help advance our understanding of core issues raised by the enhancement uses of the emerging biomedical technologies. The second is when, inevitably, our discussion of biomedical enhancements uncovers insights that reflect back upon the ethical dimensions of these other practices.