 Big Data promises to revolutionise the production of knowledge within and beyond science, by enabling novel, highly efficient ways to plan, conduct, disseminate and assess research. The last few decades have witnessed the creation of novel ways to produce, store, and analyse data, culminating in the emergence of the field of data science, which brings together computational, algorithmic, statistical and mathematical techniques towards extrapolating knowledge from big data. At the same time, the Open Data movement—emerging from policy trends such as the push for Open Government and Open Science—has encouraged the sharing and interlinking of heterogeneous research data via large digital infrastructures. The availability of vast amounts of data in machine-readable formats provides an incentive to create efficient procedures to collect, organise, visualise and model these data. These infrastructures, in turn, serve as platforms for the development of artificial intelligence, with an eye to increasing the reliability, speed and transparency of processes of knowledge creation. Researchers across all disciplines see the newfound ability to link and cross-reference data from diverse sources as improving the accuracy and predictive power of scientific findings and helping to identify future directions of inquiry, thus ultimately providing a novel starting point for empirical investigation. As exemplified by the rise of dedicated funding, training programmes and publication venues, big data are widely viewed as ushering in a new way of performing research and challenging existing understandings of what counts as scientific knowledge.