 The precise details of rapidly developing empirical science will improve our understanding of the extent to which there is a determinate relationship between contemporary humans’ genome and their physical, psychological and behavioural properties. There is, however, little plausibility that the blueprint metaphor might be applicable to the way DNA is transcribed, translated and interacts with its cellular environment. Such interaction is itself subject to influence by the organism’s external environment, including its social environment (Dupré 2001: 29ff.; 2003: 111ff.; Griffiths 2011: 326; Prinz 2012: 17ff.; Griffiths &amp; Tabery 2013: 71ff.; Griffiths &amp; Stotz 2013: 98ff., 143ff.). For example, the feature of contemporary human life for which there must according to Aristotle be some kind of blueprint, viz. rational agency, is, as Sterelny has argued, so strongly dependent on social scaffolding that any claim to the effect that human rationality is somehow genetically programmed ignores the causal contributions of manifestly indispensable environmental factors (Sterelny 2018: 120).