More recent evaluations of chimeras in traditional animal ethics terms include work by Shaw, Dondorp, &amp; de Wort (2014), who apply a three R’s framework (focusing on reduction, refinement, and replacement) to argue for a generally favorable conclusion regarding the use of chimeric non-human primates as a source of organs for xenotransplantation. (For a critical response, see Palacios-Gonzàles (2016)).