 And it is not just the quantity of data and the many new “-omes” that researchers now work with that have transformed the science. As we have pointed out in several places, insights into the genome and its functioning have transformed researchers’ understanding of the entities and processes they are working with in the course of the last few decades. Part of this was also a transformation in our understanding of what it means to do ‘good’ science. What the HPG and its various offshoots have achieved, therefore, is to change the life sciences at the epistemological, the ontological and also the methodological level.