 The issue which has shaped debates over scientific method the most in the last half century is the question of how pluralist do we need to be about method? Unificationists continue to hold out for one method essential to science; nihilism is a form of radical pluralism, which considers the effectiveness of any methodological prescription to be so context sensitive as to render it not explanatory on its own. Some middle degree of pluralism regarding the methods embodied in scientific practice seems appropriate. But the details of scientific practice vary with time and place, from institution to institution, across scientists and their subjects of investigation. How significant are the variations for understanding science and its success? How much can method be abstracted from practice? This entry describes some of the attempts to characterize scientific method or methods, as well as arguments for a more context-sensitive approach to methods embedded in actual scientific practices.