 It has been well known that certain surgical procedures, some drugs and certain pathological conditions reduce or remove the unpleasantness of pain while preserving its sensory-discriminative aspect. These data typically come from patients who have undergone prefrontal lobotomy (Freeman et al. 1942; Freeman and Wattz 1946, 1950; Hardy et al. 1952; Barber 1959; Bouckoms 1994) or cingulotomy (Foltz and White 1962a, 1962b; White and Sweet 1969) as a last resort for their intractable chronic pain (as frequently involved in phantom limb pain, neuralgia, causalgia, severe psychogenic and cancer pains), from patients under the effects of hypnotic suggestion (Barber 1964; Rainville et al. 1997, 1999), nitrous oxide (laughing gas), and some opium derivatives like morphine (Barber 1959). These patients by and large claim that they are in pain, and they can recognize and identify their pain as such, but do not feel or seem bothered or distressed in ways characteristic to having pain experiences.