 As with all such moral and political principles, questions remain about the specification of the harm principle. There are questions about the nature of harm, which is typically understood as setting back the interests of individuals in which they have rights, including economic interests. How significant must the threat of harm be, with regard to both its likelihood and  magnitude?[26]  Are physical harms to the health of others to be weighted more than economic harms or other setbacks to interests? It is undeniable that individuals have much broader and more multi-dimensional interests than narrowly self-directed physical ones. In that sense, it is not unreasonable to have a fairly expansive understanding of “harm” in a public health context. And given how self-harming behavior influences others, some might question the usefulness of sharply delineating self-regarding and other-regarding harm. Others, however, charge that to interpret harm in this way is too expansive (Jones and Bayer 2007).