There are several broad approaches to investigating the origin of life. “Bottom-Up” approaches begin with pre-biotic chemistry and explore how it could withstand stressors in order for lifelike entities to form and evolve. At present, there are many unsolved problems, most notably that most energetically favorable interactions would consume the proto-life forms involved. Scientists have cleverly attempted to ease the problem by relaxing assumptions: perhaps the environment provided our first boundaries (Koonin 2009), or perhaps it provided porto-genetic material (Mathis et al. 2017), all of this could have occurred in a viscous solvent instead of a cell (He et al. 2017), or on a surface (Wächtershäuser 1988), or using a variety of entities that eventually became encapsulated (Eigen &amp; Schuster 1977). Nevertheless, the gulf between the pre-biotic chemistry and the simplest life forms is still huge and any number of explanations only account for a tiny portion of the conceptual distance.