 The molecularization of experimental embryology is one of the most striking success stories of contemporary biology as genes and genetic interactions (e.g., in transcriptional networks and signaling pathways; see  Section 1.3)  were discovered to underlie specific details of differentiation, morphogenesis, pattern formation, and growth when structure originates during development. Genetic approaches predominate in contemporary developmental biology and physical modes of causation are often neglected. The frustration among researchers interested in physical causation during embryogenesis has been palpable.