 In the face of all this disagreement and unfinished business, biologists such as Maynard Smith (2000) maintain either that informal analyses of “information” are good enough or that some future formal version of information theory will justify the sorts of inferences that they make. The sense of “information” used in the Central Dogma of molecular biology is more like a fit of template, or the primary structure of the protein sequence compared to the sequence of the DNA base pairs. Attempts have been made in what is now known as bioinformatics to use Classical Information Theory (Shannon’s theory of communication) to extract functional and phylogenetic information (Brooks &amp; Wiley 1988; Gatlin 1972; Maclaurin 1998; Rodrick Wallace &amp; Wallace 1998), but they appear to have been unsuccessful in the main.