 Laura Candiotto (2017) argues that the best philosophical framework for RQM is Ontic Structural Realism (OSR) (Ladyman&amp; Ross 2007; French &amp; Ladyman 2011). Ontic structural realism is meant to be a defensible form of scientific realism (Ladyman 2007 [2019]); it argues for the priority of relations over substances, as self-subsistent individual objects (Morganti 2011). For Candiotto, RQM is a realistic theory that assumes the notion of relation (the physical interaction between systems and instruments) as primitive; objects emerge as relational “nodes” (French 2006), or intersections of processes. The lack of observer-independence is not inability of providing an account of the structure of matter, because there are no intrinsic properties that can be assigned to systems independently of their interactions, therefore this structure is itself relational, hence in particular observer dependent. Relations via dynamical processes of information exchange can be taken as the building blocks of the universe.