 Theoretical holism and the underdetermination of theory choice by empirical evidence are the central theses in Duhem’s philosophy of science. His argument, in brief, is that at least in sciences like physics, where experiment is dense with sophisticated instrumentation whose employment itself requires theoretical interpretation, hypotheses are not tested in isolation but only as part of whole bodies of theory. It follows that when there is a conflict between theory and evidence, the fit can be restored in a multiplicity of different ways. No statement is immune to revision because of a presumed status as a definition or thanks to some other a priori warrant, and most any statement can be retained on pain of suitable adjustments elsewhere in the total body of theory. Hence, theory choice is underdetermined by evidence.