 Granted, as noted earlier, biotechnology has a growing capacity to control conditions and harness genetically engineered organisms to produce desired products. However, to the extent that biological theory is still meant to address naturally variable populations, then concepts, methods, and models are needed through which what has been controlled or de-emphasized might be brought back and re-integrated into the scientific accounts. The framing of this entry in terms of control and reintegration has been designed to draw attention to the space around the genotype-phenotype distinction that remains open for conceptual clarification and methodological advances.