 And last but not least there was also the critique 3) that the HGP is fundamentally misguided as it assumes that by using sequence knowledge alone we would be able to develop an understanding of how our body works, how it develops disease, and that this understanding will eventually lead to cures for many diseases (Lewontin 1992; Tauber &amp; Sarkar 1992; Kitcher 1994). This more general critique of a narrowly sequence-focused approach to biomedical issues also comes up 20 years later in discussions about the use of common genetic variants to learn more about common diseases and traits (see  Section 3.1.2).  