 The case of the mesosome has attracted substantial interest from other philosophers of science. Culp (1994) challenged Rasmussen’s interpretation of the history of mesosomes, contending that the rejection of mesosomes as an artifact is in fact best explained on grounds of robustness. In particular, she points to the combined data from biochemists that revealed few differences between cytoplasmic membranes and specimens supposedly from mesosomes and from a new generation of electron microscopists that suggested that mesosomes resulted from the fixative, glutaraldehyde, used to generate the micrographs purporting to show them. These robustness considerations, she claims, sufficed to lead the community to reject mesosomes. In a later paper, Rasmussen responds to Culp’s analysis, continuing to maintain that local details, not principles like robustness, determine scientists’ judgments about artifacts: 