Whenever Spike would cry because ponies would make fun of him for being a dragon with no powers what so ever, Twilight would cradle him in her arms, and say, "It doesn't matter if you are different. Being different makes you special. And besides, being a dragon doesn't mean I don't love you." This would always stop Spike's sobbing when he was a little toddler, and Spike has since gotten over every pony's teasing.